High-impact publications

Recent PDRC Publications

  • Svahn AJ, Don EK, Badrock AP, Cole NJ, Graeber MB, Yerbury JJ, Chung R, Morsch M. Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons. Acta Neuropathol. 2018 Jun 25. doi: 10.1007/s00401-018-1875-2. [Epub ahead of print]
  • Capper MJ, Wright GSA, Barbieri L, Luchinat E, Mercatelli E, McAlary L, Yerbury JJ, O'Neill PM, Antonyuk SV, Banci L, Hasnain SS. The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation. Nature Communications 2018 Apr 27;9(1):1693. doi: 10.1038/s41467-018-04114-x
  • Whiten, DR, Cox, D, Horrocks, MH, Taylor, CG, De, S, Flagmeier, P, Tosatto, L, Kumita, JR, Ecroyd, H, Dobson, CM, Klenerman, D and Wilson, MR (2018) Single-molecule characterization of the interactions between extracellular chaperones and toxic alpha-synuclein oligomers. Cell Reports 23: 3492-3500
  • Ciryam P, Lambert-Smith I, Bean DM, Saunders DN, Wilson MR, Oliver SG, Morimoto RI, Dobson CM, Vendruscolo M, Favrin G, Yerbury JJ (2017) Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS. Proc Natl Acad Sci USA 114: E3935-E3943
  • Williams, KL …., Yerbury, JJ …and Blair, IP (2016) CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia. Nature Communications 7: 11253
  • Grad, LI*, Yerbury, JJ*, Turner, BJ*, Guest, WC, Pokrishevsky, E, O’Neill, MA, Yanai, A, Silverman, JM, Zeineddine, R, Corcoran, L, Kumita, JR, Luheshi, LM, Yousefi, M, Coleman, BM, Hill, AF, Plotkin, SS, Mackenzie, IR and Cashman, NR. (2014) Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms. Proc Natl Acad Sci USA 111: 3620-3625 * Joint first authors
  • Hochberg GKA*, Ecroyd H*, Liu C, Cox D, Cascio D, Sawaya MR, Collier MP, Stroud J, Carver JA, Baldwin AJ, Robinson CV, Eisenberg DS, Benesch JLP and Laganowsky A. (2014) The structured core domain of alphaB-crystallin can prevent amyloid fibrillation and associated toxicity. Proc Natl Acad Sci USA 111: e1562-70. * Joint first authors