Towards the Synthesis of Nitrogen Containing Heterocycles
Molecular Horizons Seminar - Liam Joyce, PhD Exit Seminar
Nitrogen containing heterocycles make the largest contribution to all new small molecular pharmaceuticals. This talk will outline efforts to synthesise novel nitrogen heterocycles by cycloisomerisation reactions of allenes and 1,3-enynes. Part 1 will involve a newly discovered Alder-ene reaction of α-allenyl propiolamides to make α-methylene-γ-lactams. Part 2 will involve the synthesis of air stable Ni(0) complexes and their use in the cycloaromatisation of 1,3-enynes to make isoindolines.