UOW visible on the side of Molecular Horizons building

Our impact

The molecular life sciences have experienced considerable growth as a UOW research strength over the past decade. This growth, coupled with the establishment of Health and Wellbeing initiative as a broader strategic direction for the University, catalysed an $80 million UOW investment into Molecular Horizons, a new molecular life sciences research Institute.

A message from the Director

"Critical to Molecular Horizon's vision is the systematic integration of cutting-edge visualisation techniques spanning from the molecular to the organismal scale with mechanistic biology and medicinal chemistry. These enabling technologies will allow transformative understanding of the molecular principles of disease and utilisation of that knowledge to identify strategies to develop novel therapeutics and diagnostics.

The 2019-2020 period brought a number of major milestones for Molecular Horizons. With our new, 6,500-m2 world-class research facility having reached completion in January 2020, our teams were eager to recommence their research and put to use the new equipment – including the brand new cryo-EM facility with its state-of-the-art equipment to determine the atomic-level structures of biological macromolecules.

Little did we know that we would be opening our Institute at the brink of a global pandemic. There is no doubt that 2020 was a disruptive and challenging year. The impact of the COVID-19 pandemic on our lives started a process that saw the world changed in many ways. With our colleagues and students living in periods of extended lockdowns, teaching staff facilitating the transition of all UOW’s teaching to online platforms, colleagues feeling the financial realities of the university environment during COVID, adapting to new COVID-safe practices, and juggling the consequential mental pressures, adjusting to the new normal impacted us all.

Despite the new challenges we were facing, Molecular Horizons has demonstrated an excellent few years of impactful research and wonderful highlights, all described in this report. In the 2019-2020 period alone, our researchers have been awarded over 90 grants and have published more than 340 publications. Some other notable achievements include the prestigious fellowships, scientific awards and many other accolades that are a testament to the exceptional talent within our Institute. 

Molecular Horizons partners with industry, government, universities and community partners to cultivate highly integrated research programs that transcend traditional, individual project-based efforts, to deliver outcomes of increased scale, scope and impact. Underpinned by a strong institutional culture of creativity, innovation and collegiality our mission is to translate basic molecular understanding into real-world applications and, in doing so, recruit and train the next generation of interdisciplinary life scientists.

Antoine van Oijen

In this highly multidisciplinary environment, Molecular Horizons members have provided joint supervision of Honours and HDR students, coordinated exchange programs, co-authored publications and grants, and successfully graduated over 50 postgraduate students in the 2019-2020 period, many with awards, prizes, and first author publications in high-impact journals.

Lastly, I would like to acknowledge and thank all staff and student members for their resilience, endurance and exceptional strength that has been shown in abundance during this time. We should be extremely proud of the quality of our research whilst navigating the obstacles the pandemic created in all aspects of our lives. Also, I would like to thank all our partners for helping us grow as an Institute. In particular, I am grateful for our generous donors joining and supporting us on this exciting journey. It is my pleasure to celebrate with you a wonderful first two years of Molecular Horizons."

Distinguished Professor Antoine van Oijen
Director, Molecular Horizons

The transformational research of Molecular Horizons is underpinned by offering internal and external researchers access to world-class research infrastructure. High-end core facilities are key drivers of the mission of Molecular Horizons, providing opportunities for cutting-edge and collaborative research. In doing so, this state-of-the-art infrastructure lies at the heart of the Molecular Horizons vision “that seeing is believing". Professor Heath Ecroyd Associate Dean (Research), Faculty of Science, Medicine and Health

Our impact

Developing anti-cancer drugs with industry

Molecular Horizons researcher Dr Carolyn Dillon and her research team have entered a joint venture licencing agreement with the Australian Pharmaceutical Company, Phebra. The agreement stems from an ongoing UOW/Phebra relationship that was established in 2016 following Dr Dillon’s conception of a class of arsenic compounds that selectively target specific cancers. 

The concept was patented internationally in 2019 and Phebra has funded further patents across the Americas, Asia, Europe and the Middle East. The collaboration utilises the expertise of Dr Dillon’s research group in the areas of synthesis, characterisation, purification and in vitro biological testing to design and identify candidates for in vivo assessment. The most promising compound, to date, targets and kills leukemia cells over healthy blood cells with one thousand times greater selectivity.

The collaboration provides invaluable insight into the development and manufacturing of drugs by the pharmaceutical industry for postgraduate and undergraduate medicinal chemistry students at UOW.

Carolyn Dillon Molecular Horizons Researcher

Microprobe XRF imaging showing arsenic uptake and distribution throughout both the cytoplasm and nucleus of a leukemia cell following treatment with the potential arsenic drug.

Industry projects

  • Grünenthal (through Uniquest): $1.2M (2019-2020) to D/Prof David Adams
    Development of peptide therapeutics
  • GenieUs Genomics: $511k (2019-2020) to A/Prof Lezanne Ooi
    Tarantino Project – Reprogramming fibroblasts into induced pluripotent stem cells
  • Phebra Pharmaceutical Development and Manufacturing: $213k to Dr Carolyn Dillon
    Synthesis and biological assessment of Arsenic-based leukemia and pancreatic homing complexes
  • US Army Medical Research: $118k to S/Prof Mark Wilson and Prof Heath Ecroyd
    Rapid Flow Cytometry Screen for Identifying Novel ALS Drug Leads
  • DSM Nutritional Products: $100k (2019) to Prof Barbara Meyer
    Can Omega3 and/or Multivitamins & Mineral Supplementation Enhance Behavioural Self-control

We gratefully acknowledge the individuals and organisations that donated to Molecular Horizons in 2019 and 2020. COVID-19 made 2020 a challenging year, but it is in large part due to our meaningful community connections that we were able to continue to empower and support our researchers. Those donations have allowed us to provide our junior researchers with the extra support that has proven so critical in times of uncertainty and reduced government funding. It demonstrates the power of working together with the community to do high-impact research and fuel the breakthroughs that can change lives.

In appreciation

A special thank you to the following individuals for their generosity:

  • Madeline Tynan and family ($66,000)
  • Professor Bruce Warren ($38,000)
  • And our anonymous donors ($300,000)

Michael Tynan Challenge

The Michael Tynan Challenge (MTC) was created in dedication of Michael Tynan, OAM, who sadly passed away in February 2016 after a two-year fight with cancer. It was Michael’s dedication to community and family that inspired his daughter, Tynan Motors Group Director Madeline Tynan, to establish the MTC in 2016. The MTC’s goal is to raise funds that contribute to medical health research that will save lives and create better health outcomes within the community.

We are incredibly honoured and grateful to be invited to participate in the various fundraiser activities set out by the MTC throughout the year, including the Race Day Luncheon and the Coastal Walk Challenge. The funds raised from these activities have enabled us to establish scholarships supporting undergraduate students during their fourth-year honours projects. Embedded in the research groups in Molecular Horizons, these students use the final year of their studies to conduct impact-driven research that contributes to solving global health challenges such as motor neurone disease, Alzheimer’s, cancer therapeutics, molecular neuroscience and protein aggregation related diseases. During 2019 and 2020, we have been able to support 11 students with a Tynan Family Molecular Horizons Honours Scholarship.

"As a family, we are passionate about giving back to the community that supports our family business."
 "We are delighted to support the development taking place in the medical research facilities at UOW, which is assisting not only the local but broader community, especially at a time when the importance of medical research is so evident today, during this epidemic, for both physical and mental health."  - Madeline Tynan

 

The Centre for Oncology Education & Research Translation (CONCERT)

CONCERT was established in 2014 as part of the Cancer Institute NSW (CINSW) initiative for Translational Cancer Research Centres (TCRC). CONCERT brought together the knowledge and expertise of cancer health professionals & researchers from 10 institutions and 3 local health districts hospitals across Sydney and the Illawarra/Shoalhaven to facilitate translation of cancer research to achieve better outcomes for those affected by cancer.  CONCERT has recently transitioned into a new larger entity called the Sydney Partnership for Health, Education, Research and Enterprise (SPHERE) Cancer Clinical Academic Group (CAG), which was recently awarded a $7million Translational Cancer Research Capacity Building Grant from Cancer Institute NSW. During its 7 years of operation CONCERT became a 370 member strong cancer research network with overarching Targets and Therapeutics (coordinated by Prof Ranson from MH/IHMRI who has also acted as Deputy Director of CONCERT) and Policy and Practice flagship programmes. This includes the ongoing CONCERT Biobank which has collected over 35,000 samples for over 40 research projects to date. There is now a fully developed process for routine patient sample collection and analysis within the Illawarra and across the CONCERT network, with firm research links established to other clinical and academic institutes in NSW. The access to patient samples with linked clinical data is informing biomarker discovery for diagnostic, prognostic and/or predictive (e.g., drug responsiveness) analyses. For example, we established patient-derived cultures from gastric cancer circulating tumour cells as avatars for drug responsiveness studies in this disease.

Fluorescence microscopy image of patient-derived gastric cancer circulating tumour cells showing staining for DNA (DAPI, blue) and the cellular structural component Actin (red). These cells are also highly positive for the cell surface growth factor receptor EGFR (green), whose overexpression is often a feature of rapidly growing and invasive cancer cells. Drugs blocking EGFR can be used to limit gastric cancer spread.

  • Australian Research Council Industrial Transformation Training Centre for Cryo-EM on Membrane Proteins (CCeMMP): Monash University, University of Melbourne, WEHI, University of Wollongong (2020)
  • Wollongong Antimicrobial Resistance Research Alliance (WARRA): Illawarra Shoalhaven Health District, NSW Health Pathology, Southern.IML/Sonic, University of Wollongong (2019-2020)
  • Centre for Oncology Education & Research Translation (CONCERT): UNSW, Western Sydney University, Ingham Institute for Applied Medical Research, South Western Sydney Local Health District, Illawarra Shoalhaven Local Health District, Illawarra Health and Medical Research Institute, Health Directorate ACT Government, Australian National University, University of Canberra, University of Wollongong (2019-2020)
  • The Australian Characterisation Commons at Scale (ACCS): Monash University: AARNet, Bioplatforms Australia, Flinders University, EMBL Australia, Microscopy Australia, National Imaging Facility, Pawsey Supercomputing Centre, QCIF, RMIT University, Swinburne University, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, University of New South Wales, University of Queensland, University of South Australia, University of Sydney, University of Western Australia, University of Wollongong (2020)

Hand sanitiser to protect local healthcare workers

Molecular Horizons and Illawarra Shoalhaven Local Health District join forces to bolster local hand sanitiser stocks Critical shortages of medical supplies have been a worldwide problem in the fight against the COVID-19 pandemic. But experts in the Illawarra have come up with their own solution.

Read more

Where are they now?

Our students and their journeys

Dr San Gil was awarded a PhD from the University of Wollongong in 2018. Her PhD research was done in Molecular Horizons under the primary supervision of Prof Heath Ecroyd and co-supervised by A/Prof Lezanne Ooi and Prof Justin Yerbury. Together, they discovered that neurodegenerative disease-associated stresses escape the detection of protective responses in brain cells, leaving them susceptible to cell death. Dr San Gil travelled to London in 2016 to undertake an Endeavour Research Fellowship at the Institute of Neurology, University College London. Recently, she was appointed as the inaugural Fight MND Early Career Research Fellow at the Queensland Brain Institute, University of Queensland, where Dr San Gil works in Dr Adam Walker’s laboratory. In this position, she is working towards advancing our understanding of the genes and biological processes driving protein aggregation and neurodegeneration in motor neuron disease.

Image of UOW alumni Rebecca San Gil

Dr Kimberley Davis completed her PhD in 2015 in what was then the UOW School of Chemistry, under the supervision of Molecular Horizons researchers Prof Stephen Ralph, Prof Jenny Beck and Dr Chris Richardson. Although a chemist by background, Dr Davis was able to branch out into the biomolecular sphere, investigating how a range of nickel Schiff base complexes she synthesised interacted with Quadruplex DNA, a structure which is implicated in tumour immortality.

Since then, Dr Davis has worked in a diverse range of areas – science communication, academic teaching, lab-based work, and community engagement. Dr Davis: ‘Some of these appear to have no relation to my PhD! However, I can safely say that a PhD isn’t just about domain knowledge; you learn a great many more things, but most of all how to adapt and how to continuously learn.’

Dr Davis has now moved into the Clinical Research sphere, as part of the Research Operations team for the Illawarra Shoalhaven Local Health District, joining in mid-2020. Despite having no clinical background, she has been able to readily transition into this space, working with clinicians in a range of disciplines and assisting with their projects – very much like an all-areas Clinical Post-Doc. She has already published with ISLHD clinicians in both General and Orthopaedic surgery, and is currently working on papers for Aged Care and Emergency Stroke assessment, as well as being involved in projects in areas such as Health Information Management, Pharmacy, Cardiology, Cancer prognostics, and much more.

Photo of UOW alumni Kimberley Davis

Dr Sandeep Satapathy received his PhD based on work with Molecular Horizons researcher Prof Mark Wilson. His research project was based on understanding the structure-function relationship of secreted chaperones, proteins that guard the folding and stability of other proteins. During his PhD he has successfully established the first rapid and high-yield mammalian expression system of the very difficult to express protein clusterin and establish a detailed understanding of the role of clusterin in intracellular protein quality control. Subsequently, he was awarded a Harvard Post-Doctoral Research Fellowship, allowing Dr Satapathy to work in world-class labs in the Blavatnik Institute of Cell Biology at Harvard Medical School and The Broad Institute. Expanding on his research interests in understanding the biological roles of the secretome, his current work is focused on the role of secretory proteins in the molecular regulation of pancreatic beta cells. As a trained cell and molecular biologist, Dr Satapathy enjoys asking questions and finding meaningful answers to the signaling and molecular crosstalk of proteins associated with serious human diseases like Alzheimer’s disease and diabetes.

Image of UOW alumni Sandeep Satapathy

Noteable achievements

  • 2019 NSW Tall Poppy Award: Dr Natalie Matosin
  • 2019 Wollongong Citizen of the Year: Prof Justin Yerbury
  • 2020 Rebecca L Cooper Memorial Award: Dr Natalie Matosin
  • 2020 UOW Vice-Chancellor’s Research Excellence Award for Emerging Researcher: Dr Yee Lian Chew
  • 2020 Margaret Sheil Leadership Award (Royal Australian Chemical Institute): A/Prof Danielle Skropeta
  • 2020 NSW Premier’s Prize for Science and Engineering (Medical Biological Sciences): D/Prof Antoine van Oijen
  • 2020 Order of Australia: Prof Justin Yerbury
  • 2020 NSW Master Builder Award (Excellence in Construction): Paul Wellings Building
  • 2019 National Institutes of Health (USA) Program Grant to D/Prof Antoine van Oijen, Dr Andrew Robinson and Dr Harshad Ghodke (in collaboration with University of Wisconsin, Madison and University of Southern California) ($1.5M to Molecular Horizons)
    ‘Creation and Repair of Postreplicative DNA Gaps’
  • 2019 ARC Future Fellowship to Dr Shane Ellis ($734k)
    ‘Mapping dynamic lipid biochemistry with high spatial and molecular detail’
  • 2019 Cancer Council project grant to Dr Debbie Watson ($448k)
    ‘Immune Cell Depletion and P2X7 Receptor Blockade to Prevent Graft-versus-host Disease in Blood Cancer Treatment’
  • 2019 MRFF Frontier Stage 1 funding to multi-organisation consortium co-led by D/Prof Antoine van Oijen ($1M)
    ‘Use of disruptive technologies to trace, track and tackle antibiotic resistance’
  • 2019 Department of Defense (USA) Idea Award to S/Prof Mark Wilson and Prof Heath Ecroyd (in collaboration with University of Queensalnd and Macquarie University) ($339k to Molecular Horizons)
    ‘Rapid Flow Cytometry Screen for Identifying Novel ALS Drug Leads’
  • 2020 ARC Discovery Project to Prof Adam Trevitt ($420k)
    ‘New laser and mass spectrometry methods for detecting protonation isomers’
  • 2020 NHMRC Investigator grant to D/Prof Xu-Feng Huang ($1.5M)
    ‘Neurite deficits, obesity and cortical thinning: Prevention and treatment in schizophrenia’
  • 2020 NHMRC Investigator grant to Dr Yee-Lian Chew ($640k)
    ‘Investigating neuroendocrine dysregulation as new targets for chronic pain management’
  • 2020 NHMRC Ideas grant to Dr Gokhan Tolun ($636k)
    ‘Revealing the molecular mechanistic details of viral DNA recombination towards developing novel anti-viral drugs’
  • 2020 ARC Industrial Transformation Training Centre funding to D/Prof David Adams and D/Prof Antoine van Oijen (in collaboration with Monash University, University of Melbourne and WEHI) ($809k to Molecular Horizons)
    ‘ARC Training Centre for Cryo-electron microscopy of membrane proteins for drug discovery – CCEMMP’

*Grants received at $100,000 or more

 

National Health and Medical Research Council (NHMRC)

Neurite deficits, obesity and cortical thinning: Prevention and treatment in schizophrenia

Xu-Feng Huang (SMAH) - Staff (Chief Investigator)

$1,500,000

 

Australian Research Council (ARC)

ARC Training Centre for Cryo-electron microscopy of membrane proteins for drug discovery - CCEMMP

Antoine van Oijen (SMAH) - Staff (Chief Investigator), David Adams (SMAH) - Limited Term (General) (Chief Investigator)

$809,417

 

Australian Research Council (ARC)

Mapping dynamic lipid biochemistry with high spatial and molecular detail

Shane Ellis (SMAH) - Staff (Chief Investigator)

$734,162

 

National Health and Medical Research Council (NHMRC)

Neuronal membranes and connections in dementia: targets for intervention

Lezanne Ooi (SMAH) - Staff (Fellow Other)

$720,144

 

National Health and Medical Research Council (NHMRC)

Investigating neuroendocrine dysregulation as new targets for chronic pain management

Yee Lian Chew (SMAH) - Staff (Chief Investigator)

$639,750

 

National Health and Medical Research Council (NHMRC)

Revealing the molecular mechanistic details of viral DNA recombination towards developing novel anti-viral drugs

Gokhan Tolun (SMAH) - Staff (Chief Investigator), Antoine van Oijen (SMAH) - Staff (Chief Investigator)

$636,368

 

 

National Health and Medical Research Council (NHMRC)

Exposures of mobile phone radiofrequency electromagnetic energy in juveniles: effects on brain development and behaviours

Chao Deng (SMAH) - Staff (Chief Investigator), Rodney Croft (ASSH) - Staff (Chief Investigator)

$632,100

 

National Health and Medical Research Council (NHMRC)

Repurposing Amiloride into Breast Cancer Drugs with a Dual-Targeting Mechanism

Michael Kelso (SMAH) - Staff (Chief Investigator), Marie Ranson (SMAH) - Staff (Chief Investigator)

$606,966

 

National Health and Medical Research Council (NHMRC)

Understanding the mechanisms for ameliorating/preventing antipsychotic-induced obesity in early life

Chao Deng (SMAH) - Staff (Chief Investigator), Jiamei Lian (SMAH) - Staff (Chief Investigator)

$576,496

 

Human Frontier Science Program

High-throughput single-molecule evolution

Antoine van Oijen (SMAH) - Staff (Chief Investigator)

$545,663

 

Australian Research Council (ARC)

Molecular Interactions with an Antibiotic Target in DNA Replication

Nicholas Dixon (SMAH) - Staff (Chief Investigator), Aaron Oakley (SMAH) - Staff (Chief Investigator), Andrew Robinson (SMAH) - Staff (Chief Investigator), Michael Kelso (SMAH) - Staff (Chief Investigator)

$534,573

 

Australian Research Council (ARC)

A functional dissection of the bacterial replisome

Antoine van Oijen (SMAH) - Staff (Chief Investigator), Nicholas Dixon (SMAH) - Staff (Chief Investigator)

$524,298

 

National Health and Medical Research Council (NHMRC)

From lead compounds to potential therapeutics: Drugs to treat Clostridium Difficile Infections

Stephen Pyne (SMAH) - Staff (Chief Investigator), Paul Keller (SMAH) - Staff (Chief Investigator)

$523,460

 

Australian Research Council (ARC)

Defining systems that clear dangerous misfolded proteins from body fluids

Mark Wilson (SMAH) - Staff (Chief Investigator), Heath Ecroyd (SMAH) - Staff (Chief Investigator)

$452,800

 

Cancer Council

Immune Cell Depletion and P2X7 Receptor Blockade to Prevent Graft-versus-host Disease in Blood Cancer Treatment

Debbie Watson (SMAH) - Staff (Chief Investigator)

$448,365

 

Australian Research Council (ARC)

New laser and mass spectrometry methods for detecting protonation isomers

Adam Trevitt (SMAH) - Staff (Chief Investigator)

$420,000

 

Australian Research Council (ARC)

Shared Picosecond-Laser Facility

Adam Trevitt (SMAH) – Staff (Chief Investigator), Attila Mozer (AIIM) - Staff (Chief Investigator)

$417,900

 

National Institute of Health (NIH)

Creation and Repair of Postreplicative DNA Gaps

Antoine van Oijen (SMAH) - Staff (Chief Investigator), Harshad Ghodke (SMAH) - Staff (Fellow Other), Andrew Robinson (SMAH) - Staff (Chief Investigator), Nicholas Dixon (SMAH) - Staff (Chief Investigator)

$379,914

 

Health Research Council of New Zealand (HRC)

Repurposing Amiloride Derivatives as New Agents for Drug-Resistant Tuberculosis

Michael Kelso (SMAH) - Staff (Chief Investigator)

$364,077

 

Australian Research Council (ARC)

A New Molecular Platform for Catalytic Synthesis of Heterocycles

Stephen Pyne (SMAH) - Staff (Chief Investigator), Christopher Hyland (SMAH) - Staff (Chief Investigator)

$357,072

 

Australian Research Council (ARC)

Superresolution fluorescence imaging in microbiology

Antoine van Oijen (SMAH) - Staff (Chief Investigator), Nicholas Dixon (SMAH) - Staff (Chief Investigator)

$355,000

 

National Health and Medical Research Council (NHMRC)

Antibiotic resistance: combining microscopy, microfluidics and genomics to target bacterial DNA repair pathways

Andrew Robinson (SMAH) - Staff (Chief Investigator), Antoine van Oijen (SMAH) - Staff (Chief Investigator), Harshad Ghodke (SMAH) - Staff (Associate Investigator), Spyridon Miyakis (SMAH) - Staff (Associate Investigator), Peter Newton (SMAH) - Honorary Fellow (Associate Investigator)

$352,859

 

Nanoparticle-Mediated Gene Delivery of Frataxin to Neurons

Mirella Dottori (SMAH) - Staff (Chief Investigator)

$341,763

 

National Health and Medical Research Council (NHMRC)

Blood group antigen recognition by Group A Streptococcus mediates host colonisation

Martina Sanderson-Smith (SMAH) - Staff (Chief Investigator)

$340,821

 

Department of Defence (DoD)

Rapid Flow Cytometry Screen for Identifying Novel ALS Drug Leads

Mark Wilson (SMAH) - Staff (Chief Investigator), Heath Ecroyd (SMAH) - Staff (Chief Investigator)

$339,360

 

National Health and Medical Research Council (NHMRC)

The role of mutant cyclin F in amyotrophic lateral sclerosis

Justin Yerbury (SMAH) - Staff (Chief Investigator), Lezanne Ooi (SMAH) - Staff (Chief Investigator)

$331,483

 

National Health and Medical Research Council (NHMRC)

Early antipsychotic exposure during childhood and adolescence: Does it lead to long term brain and behaviour changes in adulthood?

Jiamei Lian (SMAH) - Staff (NHMRC Early Career Fellowship)

$318,768

 

National Health and Medical Research Council (NHMRC)

Early antipsychotic exposure during childhood and adolescence: Does it lead to long term brain and behaviour changes in adulthood?

Jiamei Lian (SMAH) - Staff (NHMRC Early Career Fellowship)

$318,768

 

Australian Research Council (ARC)

ARC Research Hub for Australian Steel Innovation

Paul Zulli (EIS) - Staff (Chief Investigator), Brian Monaghan (EIS) - Staff (Chief Investigator), Jason Hodges (EIS) - Faculty Honorary Fellow (Partner Investigator), Sheng Chew (EIS) - Faculty Honorary Fellow (Partner Investigator), Lip Teh (EIS) - Staff (Chief Investigator), Prabuono Kosasih (EIS) - Staff (Chief Investigator), Stephen Van Duin (EIS) - Staff (Chief Investigator), Christopher Richardson (SMAH) - Staff (Chief Investigator), Paul Cooper (EIS) - Staff (Chief Investigator), Elena Pereloma (EIS) - Staff (Chief Investigator), Huijun Li (EIS) - Staff (Chief Investigator), David Pinson (EIS) - Faculty Honorary Fellow (Partner Investigator), Yue Zhao (EIS) - Staff (Chief Investigator), Azdiar Gazder (AIIM) - Staff (Chief Investigator), William Scott (EIS) - Staff (Chief Investigator)"

$316,563

 

Australian Research Council (ARC)

Electrophysiology Facility for Cell Phenotyping and Drug Discovery

David Adams (SMAH) - Limited Term (General) (Chief Investigator), Jeremy Crook (AIIM) - Staff (Chief Investigator), Lezanne Ooi (SMAH) - Staff (Chief Investigator), Robert Kapsa (AIIM) - Staff (Chief Investigator)

$284,656

 

Australian Research Council (ARC)

New photoinitiators and polymers for tack-free LED cured surface coatings

Paul Keller (SMAH) - Staff (Chief Investigator), Adam Trevitt (SMAH) - Staff (Chief Investigator), Dianne Jolley (SMAH) - Staff (Chief Investigator)

$230,000

 

National Health and Medical Research Council (NHMRC)

Structure and function of a cancer-linked co-regulator complex

Antoine van Oijen (SMAH) - Staff (Chief Investigator)

$213,748

 

National Health and Medical Research Council (NHMRC)

Building an immunocompetent Alzheimer's disease brain-on-a-chip

Lezanne Ooi (SMAH) - Staff (Chief Investigator)

$202,884

 

Motor Neurone Disease Research Institute Australia

Proteome homeostasis dysfunction in axon terminals as a cause of MND

Justin Yerbury (SMAH) - Staff (Chief Investigator), Lezanne Ooi (SMAH) - Staff (Chief Investigator)

$201,000

 

National Health and Medical Research Council (NHMRC)

Cutaneous Squamous Cell Carcinoma: defining prognostic markers of metastasis

Marie Ranson (SMAH) - Staff (Chief Investigator), Bruce Ashford (SMAH) - Staff (Chief Investigator)

$199,208

 

NSW Health

Role of the intrinsic cardiac nervous system in myocardial ischaemia and arrhythmias

David Adams (SMAH) - Limited Term (General) (Chief Investigator), Alexander Harper (SMAH) - Faculty Honorary Fellow (Investigator), Leonard Arnolda (SMAH) - Staff (Investigator)

$185,905

 

University Of Wollongong

The IVIS SpectrumCT preclinical in vivo imaging system

Kara Perrow (SMAH) - Staff (Chief Investigator), Marie Ranson (SMAH) - Staff (Chief Investigator), Mark Wilson (SMAH) - Staff (Chief Investigator), Heath Ecroyd (SMAH) - Staff (Chief Investigator), Ronald Sluyter (SMAH) - Staff (Chief Investigator), Moeava Tehei (EIS) - Staff (Chief Investigator), Carolyn Dillon (SMAH) - Staff (Chief Investigator), Martina Sanderson-Smith (SMAH) - Staff (Chief Investigator), Chao Deng (SMAH) - Staff (Chief Investigator), Lezanne Ooi (SMAH) - Staff (Chief Investigator), Brett Garner (SMAH) - Staff (Chief Investigator), Danielle Skropeta (SMAH) - Staff (Chief Investigator), Zhilian Yue (AIIM) - Staff (Chief Investigator), Phillip Byrne (SMAH) - Staff (Chief Investigator), Kelly Newell (SMAH) - Staff (Chief Investigator)

$183,333

 

University Of Wollongong

IncuCyte S3 Live-cell imaging and analysis platform with software packages

Xu-Feng Huang (SMAH) - Staff (Chief Investigator), Lezanne Ooi (SMAH) - Staff (Chief Investigator), Chao Deng (SMAH) - Staff (Chief Investigator), David Adams (SMAH) - Limited Term (General) (Chief Investigator), Heath Ecroyd (SMAH) - Staff (Chief Investigator), Kara Perrow (SMAH) - Staff (Chief Investigator), Justin Yerbury (SMAH) - Staff (Chief Investigator), Katrina Green (SMAH) - Staff (Chief Investigator), Nadia Solowij (ASSH) - Staff (Chief Investigator), Zhilian Yue (AIIM) - Staff (Chief Investigator), Konstantin Konstantinov (AIIM) - Staff (Chief Investigator), Kelly Newell (SMAH) - Staff (Chief Investigator), Mark Wilson (SMAH) - Staff (Chief Investigator), Haibo Yu (SMAH) - Staff (Chief Investigator)

$176,707

 

National Health and Medical Research Council (NHMRC)

The role of mutant CYLD in frontotemporal dementia and motor neuron disease

Lezanne Ooi (SMAH) - Staff (Chief Investigator)

$170,999

 

Australian Research Council (ARC)

Pluses and minuses of lipid mass spectrometry

Todd Mitchell (SMAH) - Staff (Chief Investigator)

$163,750

 

University Of Wollongong

Ultra Performance Liquid Chromatography-Mass Spectrometry for Chiral and Achiral Analysis

Danielle Skropeta (SMAH) - Staff (Chief Investigator), Stephen Pyne (SMAH) - Staff (Chief Investigator), Paul Keller (SMAH) - Staff (Chief Investigator), Michael Kelso (SMAH) - Staff (Chief Investigator), Christopher Hyland (SMAH) - Staff (Chief Investigator), Celine Kelso (SMAH) - Staff (Chief Investigator), Carolyn Dillon (SMAH) - Staff (Chief Investigator), Christopher Richardson (SMAH) - Staff (Chief Investigator), Yusuke Yamauchi (AIIM) - Staff (Chief Investigator), Dianne Jolley (SMAH) - Staff (Chief Investigator), Barbara Meyer (SMAH) - Staff (Chief Investigator), Marie Ranson (SMAH) - Staff (Chief Investigator), Kara Perrow (SMAH) - Staff (Chief Investigator)

$161,538

 

University Of Wollongong

Single Crystal X-ray Crystallography for the Structure Determination of Molecules and Materials at UOW

Christopher Richardson (SMAH) - Staff (Chief Investigator), Stephen Pyne (SMAH) - Staff (Chief Investigator), Paul Keller (SMAH) - Staff (Chief Investigator), Stephen Ralph (SMAH) - Staff (Chief Investigator), Michael Kelso (SMAH) - Staff (Chief Investigator), Danielle Skropeta (SMAH) - Staff (Chief Investigator), Aaron Oakley (SMAH) - Staff (Chief Investigator), Christopher Hyland (SMAH) - Staff (Chief Investigator), Carolyn Dillon (SMAH) - Staff (Chief Investigator), David Officer (AIIM) - Staff (Chief Investigator), Gerhard Swiegers (AIIM) - Staff (Chief Investigator), Pawel Wagner (AIIM) - Staff (Chief Investigator), Zhenguo Huang (AIIM) - Staff (Chief Investigator), David Wexler (AIIM) - Staff (Chief Investigator), David Wexler (EIS) - Staff (Chief Investigator)

$159,326

 

National Health and Medical Research Council (NHMRC)

Harnessing the human postmortem brain to elucidate changes in FK506 binding protein (FKBP5) in the neuropathology of severe psychiatric disorders

Natalie Matosin (SMAH) - Student (NHMRC Early Career Fellowship)

$158,596

 

National Health and Medical Research Council (NHMRC)

Australian Centre for Cannabinoid Clinical and Research Excellence (ACRE): Quality and safety in the implementation of medicinal cannabis use in the community

Nadia Solowij (ASSH) - Staff (Chief Investigator), Xu-Feng Huang (SMAH) - Staff (Chief Investigator), Kathleen Eagar (BAL) - Staff (Chief Investigator)

$158,553

 

National Health and Medical Research Council (NHMRC)

Anti-sporulation strategies for Clostridium difficile infections

Stephen Pyne (SMAH) - Staff (Chief Investigator), Paul Keller (SMAH) - Staff (Chief Investigator), Haibo Yu (SMAH) - Staff (Chief Investigator)

$157,673

 

Cancer Institute NSW

Reducing the Morbidity of Head and Neck Cancer Treatment

Bruce Ashford (SMAH) - Staff (Chief Investigator), Marie Ranson (SMAH) - Staff (Chief Investigator), Gordon Wallace (AIIM) - Staff (Chief Investigator)

$143,333

 

Cancer Australia

Implantable drug-eluting device: localised drug delivery for non-resectable pancreatic cancer

Kara Perrow (SMAH) - Staff (Chief Investigator), Morteza Aghmesheh (SMAH) - Honorary Fellow (Chief Investigator)

$139,719

 

University Of Wollongong

Influences and barriers to responsible use of antibiotics: The 21st century health challenge

Christopher Degeling (ASSH) - Staff (Chief Investigator), Mitchell Byrne (ASSH) - Staff (Chief Investigator), Antoine van Oijen (SMAH) - Staff (Chief Investigator)

$116,667

 

Motor Neurone Disease Research Institute Australia

Astrocytic modulation of neuronal excitability and cell death in Motor Neurone Disease

Lezanne Ooi (SMAH) - Staff (Chief Investigator), Justin Yerbury (SMAH) - Staff (Investigator)

$100,000

 

Rebecca L Cooper Medical Research Foundation

Unravelling the contribution of early life stress to psychopathology - a morphological study

Natalie Matosin (SMAH) - Staff (Chief Investigator)

$100,000

 

Rebecca L Cooper Medical Research Foundation

Investigating nociceptor sensitisation as a target for chronic pain treatment

Yee Lian Chew (SMAH) - Staff (Chief Investigator)

$100,000

 

Motor Neurone Disease Research Institute Australia

Targeting cortical hyperexcitability and neurodegeneration in amyotrophic lateral sclerosis

Lezanne Ooi (SMAH) - Staff (Chief Investigator)

$100,000

Timothy Ablott, School of Chemistry and Molecular Bioscience
Supervisor: Doctor Christopher Richardson
Thesis title: Advancing Underexplored Post-Synthetic Chemistry in Metal-Organic Frameworks

Sam Adhikary, School of Chemistry and Molecular Bioscience
Supervisor: Doctor Debbie Watson
Thesis title: Therapeutic Strategies to Prevent Graft-Versus-Host Disease

Ayedh Alqarni, School of Medicine
Supervisor: Professor Barbara Meyer
Thesis title: Investigation of alteration in erythrocyte lipids in people at ultra-high risk of developing psychosis

Umar Ali, School of Chemistry and Molecular Bioscience
Supervisor: Professor Marie Ranson
Thesis title: Characterisation of the Urokinase Plasminogen Activation (uPA) System in the Rat Collagen Induced Arthritis Model: Pharmacological Investigations of Methotrexate and uPA Inhibition

Bruce Ashford, School of Chemistry and Molecular Bioscience
Supervisor: Professor Marie Ranson
Thesis title: The mutational landscape of metastatic cutaneous squamous cell carcinoma

Monique Bax, School of Chemistry and Molecular Bioscience
Supervisor: Associate Professor Lezanne Ooi
Thesis title: Examination of the Ubiquitin Proteasome System in Induced Pluripotent Stem Cell Derived Motor Neurons, and Related Cell Types in the Context of Amyotrophic Lateral Sclerosis

Lisa Belfiore, School of Chemistry and Molecular Bioscience
Supervisor: Doctor Kara Perrow
Thesis title: Development of Ligand-Directed Drug-Loaded Liposomes to Target Heterogeneous Tumour Cell Populations in Metastatic Breast Cancer

Ronald Brown, School of Chemistry and Molecular Bioscience
Supervisor: Associate Professor Christopher Hyland
Thesis title: Drug Development for Neglected Diseases and Palladium Catalysis in Reaction Development

Daniel Brungs, School of Chemistry and Molecular Bioscience
Supervisor: Professor Marie Ranson
Thesis title: Molecular and clinical biomarkers in gastrointestinal cancer

Macguire Bryant, School of Chemistry and Molecular Bioscience
Supervisor: Doctor Christopher Richardson
Thesis title: Post-Synthetic Reactivity in Metal-Organic Frameworks

Nicholas Butler, School of Chemistry and Molecular Bioscience
Supervisor: Professor Paul Keller
Thesis title: Old Dye, New Tricks? Diversity-Oriented Synthesis of Heterocycles from Cascade Reactions of Indigo

Judith Carrall, School of Chemistry and Molecular Bioscience
Supervisor: Doctor Carolyn Dillon
Thesis Title: Designing tumour-targeting arsenic anti-cancer agents

Anthony Carroll, School of Chemistry and Molecular Bioscience
Supervisor: Senior Professor Stephen Pyne
Thesis title: Total synthesis of eleven hyacinthacine C-type analogues and the correction of the structures of natural hyacinthacine C1 and C5

Christiana Dawurung, School of Chemistry and Molecular Bioscience
Supervisor: Senior Professor Stephen Pyne
Thesis title: Phytochemical and Biological Studies of Selected Nigerian Traditional Medicinal Plants Used in the Treatment of Diarrhea

Christopher Dobie, School of Chemistry and Molecular Bioscience
Supervisor: Associate Professor Danielle Skropeta
Thesis title: Rational Design, Synthesis, and Biological Evaluation of Human Sialyltransferase Inhibitors

Melanie Drew, School of Chemistry and Molecular Bioscience
Supervisor: Associate Professor Christopher Hyland
Thesis title: Gold(I)-Catalysed Reactions of Cyclopropenyl Carbinol Derivatives

Peng Gao, School of Chemistry and Molecular Bioscience
Supervisor: Associate Professor Haibo Yu
Thesis title: Computer-aided Hydrogen Storage Materials Design: Accurate Predictions of NMR Chemical Shifts and MD Simulation of Nitrogen and Boron Containing Compounds

Jayden Gaston, School of Chemistry and Molecular Bioscience
Supervisor: Professor Paul Keller
Thesis title: Swimming In Chiral Pnictogen Pools - The Exploration of 3-Membered Bicyclic Chiral Pool Intermediates for the Synthesis of Libraries of Chiral 1,2-Dipnictogens

Nicholas Geraghty, School of Chemistry and Molecular Bioscience
Supervisor: Professor Ronald Sluyter
Thesis title: The Role of Purinergic Signalling in Inflammatory Disorders

Julian Harrison, School of Chemistry and Molecular Bioscience
Supervisor: Professor Jenny Beck
Thesis title: An Investigation into the Structure of Protein Toxins of Australian Snake Venoms

Sarah Henrikus, School of Chemistry and Molecular Bioscience
Supervisor: Doctor Andrew Robinson
Thesis title: Following the DNA damage response in Escherichia coli: Single-molecule studies of proteins in live cells

Han Ngoc Ho, School of Chemistry and Molecular Bioscience
Supervisor: Distinguished Professor Antoine van Oijen
Thesis title: Visualisation of Transcription-coupled Repair in Live Eschericha Coli

Venkatasaisandeep Inakollu, School of Chemistry and Molecular Bioscience
Supervisor: Associate Professor Haibo Yu
Thesis title: Computational vibrational spectroscopic studies for condensed phase systems

Jeremy Lum, School of Medicine
Supervisor: Associate Professor Kelly Newell
Thesis title: Exploring group 1 metabotropic glutamate receptors in the pathology and treatment of schizophrenia

Muni Mahadari, School of Chemistry and Molecular Bioscience
Supervisor: Senior Professor Stephen Pyne
Thesis title: Development of New Anti-Bacterial Agents

Hiwa Majed, School of Chemistry and Molecular Bioscience
Supervisor: Professor Michael Kelso
Thesis title: Synthesis and Structure-Activity Relationships of New Antibacterials Against Methicillin- Resistant Staphylococcus Aureus and Mycobacterium Tuberculosis

Patrick McCosker, School of Chemistry and Molecular Bioscience
Supervisor: Professor Paul Keller
Thesis title: Cascade Reactions of Indigo: Synthesis and Physicochemical Studies

Mohamed Metwaly, School of Chemistry and Molecular Bioscience
Supervisor: Professor Paul Keller
Thesis title: Drug design and development of antivirals and fluorescent anion transporters

Samuel Millard, School of Medicine
Supervisor: Associate Professor Kelly Newell
Thesis title: The effects of perinatal Fluoxetine treatment on offspring behaviour and neurobiology

Enrico Monachino, School of Chemistry and Molecular Bioscience
Supervisor: Distinguished Professor Antoine van Oijen
Thesis title: Dynamics of the bacterial replisome

Andrew Montgomery, School of Chemistry and Molecular Bioscience
Supervisor: Associate Professor Danielle Skropeta
Thesis title: Rational Design of Inhibitors Targeting Human Sialyltransferases

Sonia Sanz Munoz, School of Chemistry and Molecular Bioscience
Supervisor: Associate Professor Lezanne Ooi
Thesis title: Modelling the neurobiology of Alzheimer’s disease in vitro

Ashleigh Osborne, School of Medicine
Supervisor: Doctor Katrina Green
Thesis title: To CBD or Not to CBD? Understanding the Therapeutic Potential of Cannabidiol, a Component of Cannabis, for Schizophrenia

Quynh Thai Son Pham, School of Chemistry and Molecular Bioscience
Supervisor: Professor Stephen Ralph
Thesis title: Synthesis and Quadruplex DNA Binding Properties of Novel Nickel Schiff Base Complexes

Jay Perry, School of Chemistry and Molecular Bioscience
Supervisor: Professor Marie Ranson
Thesis title: Understanding the biology of metastatic cutaneous squamous cell carcinoma

Daniel Rivinoja, School of Chemistry and Molecular Bioscience
Supervisor: Associate Professor Christopher Hyland
Thesis title: Cycloaddition Reactions with 1,3-Dipoles for the Formation of Complex Heterocycles 

Lauren Roach, School of Medicine
Supervisor: Professor Barbara Meyer
Thesis title: The effect of a seaweed sulfated xylorhamnoglucuronan extract on gut, metabolic and skin health outcomes

Greg Ryder, School of Chemistry and Molecular Bioscience
Supervisor: Senior Professor Stephen Pyne
Thesis title: Latent Bis-Nucleophilic Additions to α-Cyclopropyl N-Acyliminium Ions

Sandeep Satapathy, School of Chemistry and Molecular Bioscience
Supervisor: Senior Professor Mark Wilson
Thesis title: Clusterin Enigma: Structure and Function Studies of the First Known Mammalian Secreted Chaperone

Geraud Sansom, School of Chemistry and Molecular Bioscience
Supervisor: Professor Michael Kelso
Thesis title: Anticancer Mutual Prodrugs Activated by Hypoxia

Jo Ann Seng, School of Medicine
Supervisor: Associate Professor Todd Mitchell
Thesis title: Distribution of lipids in the human lens and the effect of ageing

Reece Sophocleous, School of Chemistry and Molecular Bioscience
Supervisor: Professor Ronald Sluyter
Thesis title: Characterisation of canine P2X and P2Y receptors

Sepehr Talebian, School of Chemistry and Molecular Bioscience
Supervisor: Doctor Kara Perrow
Thesis title: Coaxial hydrogel structures for drug delivery to tumors

Srinivas Thadkapally, School of Chemistry and Molecular Bioscience
Supervisor: Associate Professor Christopher Hyland
Thesis title: Transition Metal Catalyzed [4+2]-Cycloaromatization Reactions of Unconjugated Enediynes

Heema Vyas, School of Chemistry and Molecular Bioscience
Supervisor: Associate Professor Martina Sanderson-Smith,
Thesis title: Characterising the Role of Pharyngeal Cell Surface Glycans in Group A Streptococcus Biofilm Formation

Samantha Wade, School of Chemistry and Molecular Bioscience
Supervisor: Doctor Kara Perrow
Thesis title: Fabrication and Preclinical Assessment of Drug Eluting Wet Spun Fibres for Pancreatic Cancer Treatment

Jennifer West, School of Chemistry and Molecular Bioscience
Supervisor: Senior Professor Mark Wilson
Student: Thesis title: Extracellular Chaperones and their Cell Surface Receptor

Jonathan Williams, School of Chemistry and Molecular Bioscience
Supervisor: Associate Professor Martina Sanderson-Smith
Thesis title: Characterising the Neutrophil Response to Group A Streptococcus

Hendris Wongso, School of Chemistry and Molecular Bioscience
Supervisor: Professor Paul Keller
Thesis title: The Development of Novel Fluorescent and Radiopharmaceutical Probes for Imaging Neurodegenerative Diseases

Farzad Zamani, School of Chemistry and Molecular Bioscience
Supervisor: Associate Professor Christopher Hyland
Thesis title: Synthesis and Transition Metal-catalysed Reactivity of Enantioenriched, Allenes and Enynes

Peng Zheng, School of Medicine
Supervisor: Distinguished Professor Xu-Feng Huang
Thesis title: The Mechanism of D2R Overactivation in Neurite Impairment and Oxidative Stress

2019

  •  Angewandte Chemie – International Edition (2019) 58: 6492-6501
    Reshaping Lipid Biochemistry by Pushing Barriers in Structural Lipidomics
    Tiffany Porta Siegel; Kim Ekroos; Shane Ellis

  • Angewandte Chemie – International Edition (2019) 58: 2114-2119
    Dual Gold‐Catalyzed Cycloaromatization of Unconjugated (E)‐Enediynes
    Farzad Zamani; Rasool Babaahmadi; Brian Yates; Michael Gardiner; Alireza Ariafard; Stephen Pyne; Christopher Hyland

  • Chemical Science (2019) 10: 8083-8093
    The partial dehydrogenation of aluminium dihydrides
    Thomas Hooper; Samantha Lau; Wenyi Chen; Ryan Brown; Marti Garcon; Karen Luong; Nathan Barrow; Andrew Tatton; George Sackman; Christopher Richardson
     
  • Chemical Science (2019) 10: 9051-9056
    Divergent Pd-catalyzed cross-coupling of allenyloxazolidinones to give chiral 1,3-dienes and vinyloxazolidinones
    Ronald Brown; Farzad Zamani; Michael Gardiner; Haibo Yu; Stephen Pyne; Christopher Hyland

  • Nucleic Acids Research (2019) 47: 2946-2965
    RecFOR epistasis group: RecF and RecO have distinct localizations and functions in Escherichia coli
    Sarah Henrikus; Camille Henry; Harshad Ghodke; Elizabeth Wood; Neema Mbele; Roopashi Saxena; Upasana Basu; Antoine van Oijen; Michael Cox; Andrew Robinson
     
  • Nucleic Acids Research (2019) 47: 4111-4123
    Recycling of single-stranded DNA-binding protein by the bacterial replisome
    Lisanne Spenkelink; Jacob Lewis; Slobodan Jergic; Zhi-Qiang Xu; Andrew Robinson; Nicholas Dixon; Antoine van Oijen

2020

  • Chemical Science (2020) 11: 10945-10950
    Rhodium-catalysed tetradehydro-Diels-Alder reactions of enediynes: Via a rhodium-stabilized cyclic allene
    Srinivas Thadkapally; Kaveh Farshadfar; Melanie Drew; Christopher Richardson; Alireza Ariafard; Stephen Pyne; Christopher Hyland
     
  • Molecular Cell (2020) 77: 17-25
    Tunability of DNA Polymerase Stability during Eukaryotic DNA Replication
    Jacob Lewis; Lisanne Spenkelink; Grant Schauer; Olga Yurieva; Stefan Mueller; Varsha Natarajan; Gurleen Kaur; Claire Maher; Callum Kay; Michael O'Donnell; Antoine van Oijen

  • Molecular Cell (2020) 79: 140-154
    A Primase-Induced Conformational Switch Controls the Stability of the Bacterial Replisome
    Enrico Monachino; Slobodan Jergic; Jacob Lewis; Zhi-Qiang Xu; Allen Lo; Valerie O'Shea; James Berger; Nicholas Dixon; Antoine van Oijen

  • Nature (2020) 579: 141-145
    Selective loading and processing of prespacers for precise CRISPR adaptation
    Sungchul Kim; Luuk Loeff; Sabina Colombo; Slobodan Jergic; Stan Brouns; Chirlmin Joo
     
  • Nature Communications (2020) 11: 1477
    Single-molecule live-cell imaging visualizes parallel pathways of prokaryotic nucleotide excision repair
    Harshad Ghodke; Han Ho; Antoine van Oijen

  • Nature Communications (2020) 11: 1478
    Single-molecule imaging reveals molecular coupling between transcription and DNA repair machinery in live cells
    Han Ho; Antoine van Oijen; Harshad Ghodke

  • Nature Communications (2020) 11: 1519
    CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation
    Yichen Zhong; Bishnu Paudel; Daniel Ryan; Jason Low; Charlotte Franck; Karishma Patel; Max Bedward; Mario Torrado; Richard Payne; Antoine van Oijen; Joel Mackay

Progress in Heterocyclic Chemistry

Seven-Membered Rings

Adam Meyer; Alex Bissember; Christopher Hyland; Charlotte Williams; Monika Szabo; Melanie Pearsall; Isabel Hyland; Wesley Olivier  

 

The Oxford Handbook of the Neurobiology of Pain

Invertebrate Models of Nociception: Learning from Flies and Worms

Daniel Hesselson; Denise Walker; Joshua Massingham; William Schafer; G Neely; Yee Lian Chew

 

ACS Chemical Neuroscience

(E)-3-Furan-2-yl-N-p-tolyl-acrylamide and its Derivative DM489 Decrease Neuropathic Pain in Mice Predominantly by α7 Nicotinic Acetylcholine Receptor Potentiation             

Hugo Arias; Carla Ghelardini; Elena Lucarini; Han Shen Tae; Arsalan Yousuf; Irina Marcovich; Dina Manetti; Maria Romanelli; Ana Elgoyhen; David Adams 

 

ACS infectious diseases

Discovery of Cephalosporin-3'-Diazeniumdiolates That Show Dual Antibacterial and Antibiofilm Effects against Pseudomonas aeruginosa Clinical Cystic Fibrosis Isolates and Efficacy in a Murine Respiratory Infection Model

Ardeshir Rineh; Odel Soren; Timothy McEwan; Vikashini Ravikumar; Wee Poh; Fereshteh Azamifar; M Naimi-Jamal; Chen Cheung; Alysha Elliott; Johannes Zuegg      

 

Acta Crystallographica Section E: Crystallographic Communications

Synthesis and crystal structure of (±)-Goniotamirenone C

Pornphimol Meesakul; Christopher Richardson; Surat Laphookhieo; Stephen Pyne

 

Advanced Energy Materials

Enhanced Potassium Ion Battery by Inducing Interlayer Anionic Ligands in MoS1.5Se0.5 Nanosheets with Exploration of the Mechanism

Haining Fan; Xingyong Wang; Haibo Yu; Qinfen Gu; Shan-Liang Chen; Zheng Liu; Xiao-Hua Chen; Wenbin Luo; Hua Liu

 

Advanced Energy Materials

Solvent-Dependent Singlet Fission in Diketopyrrolopyrrole Dimers: A Mediating Charge Transfer versus a Trapping Symmetry-Breaking Charge Separation 

Ilias Papadopoulos; Maria Álvaro-Martins; Desire Molina; Patrick McCosker; Paul Keller; Timothy Clark; Angela Sastre-Santos; Dirk Guldi

 

Advanced Healthcare Materials

Dual Delivery of Gemcitabine and Paclitaxel by Wet-Spun Coaxial Fibers Induces Pancreatic Ductal Adenocarcinoma Cell Death, Reduces Tumor Volume, and Sensitizes Cells to Radiation

Samantha Wade; Zeliha Sahin; Ann-Katrin Piper; Sepehr Talebian; Morteza Aghmesheh; Javad Foroughi; Gordon Wallace; Simon Moulton; Kara Perrow   

 

Alzheimer's & Dementia

Developing an ontology for representing the domain knowledge specific to non-pharmacological treatment for agitation in dementia

Zhenyu Zhang; Ping Yu; Hui Chang; Sim Lau; Cui Tao; Ning Wang; Mengyang Yin; Chao Deng

 

American Journal of Physiology - Cell Physiology

Loss of calpains-1 and -2 prevents repair of plasma membrane scrape injuries, but not small pores, and induces a severe muscular dystrophy

Ann-Katrin Piper; Reece Sophocleous; Samuel Ross; Frances Evesson; Omar Saleh; Adam Bournazos; Joe Yasa; Claudia Reed; Natalie Woolger; Ronald Sluyter  

 

Analytical and Bioanalytical Chemistry

Evaluation of lipid coverage and high spatial resolution MALDI-imaging capabilities of oversampling combined with laser post-ionisation

Andrew Bowman; Jeroen Bogie; Jerome Hendriks; Mansour Haidar; Mikhail Belov; Ron Heeren; Shane Ellis            

 

Analytical Biochemistry

Design of customizable long linear DNA substrates with controlled end modifications for single-molecule studies

Stefan Mueller; Lisanne Spenkelink; Antonius van Oijen; Jacob Lewis

 

Analytical Chemistry

Trajectory Taken by Dimeric Cu/Zn Superoxide Dismutase through the Protein: Unfolding and Dissociation Landscape Is Modulated by Salt Bridge Formation  

Luke McAlary; Julian Harrison; Andrew Aquilina; Steven Fitzgerald; Celine Kelso; Justin Benesch; Justin Yerbury

 

Analytical Chemistry

Ultra-High Mass Resolving Power, Mass Accuracy, and Dynamic Range MALDI Mass Spectrometry Imaging by 21-T FT-ICR MS 

Andrew Bowman; Greg Blakney; Christopher Hendrickson; Shane Ellis; Ron Heeren; Donald Smith

 

Analytical Chemistry

Simultaneous Detection of Zinc and Its Pathway Metabolites Using MALDI MS Imaging of Prostate Tissue

Maria Andersen; Sebastian Krossa; Therese Høiem; Rebecca Buchholz; Britt Claes; Benjamin Balluff; Shane Ellis; Elin Richardsen; Helena Bertilsson; Ron Heeren         

 

Angewandte Chemie - International Edition

How To Make Nitroaromatic Compounds Glow: Next-Generation Large X-Shaped, Centrosymmetric Diketopyrrolopyrroles  

Kamil Skonieczny; Ilias Papadopoulos; Dominik Thiel; Krzysztof Gutkowski; Philipp Haines; Patrick McCosker; Adele Laurent; Paul Keller; Timothy Clark; Denis Jacquemin      

 

Angewandte Chemie - International Edition

Stimuli-Responsive Cycloaurated “OFF-ON” Switchable Anion Transporters

Mohamed Metwaly; Xin Wu; Deepthi Ramesh; William Lewis; Paul Keller; Ethan Howe; Ricardo Perez-Tomas; Philip Gale      

 

Animal Genetics

Association of a P2RX7 gene missense variant with brachycephalic dog breeds

R Sophocleous; V Sluyter; B Curtis; S Curtis; L Jurak; M Faulks; M Spildrejorde; S Gates; E.-J Proctor; A Seavers

 

Antibiotics

Characterization of five novel anti-mrsa compounds identified using a whole-animal caenorhabditis elegans/galleria mellonella sequential-screening approach

Rajamohammed Khader; Nagendran Tharmalingam; Biswajit Mishra; Lewisoscar Felix; Frederick Ausubel; Michael Kelso; Eleftherios Mylonakis

 

Appetite

Overeating and food addiction in Major Depressive Disorder: Links to peripheral dopamine

Jessica Mills; Susan Thomas; Theresa Larkin; Chao Deng 

 

Applied Materials Today

Bipolar electroactive conducting polymers for wireless cell stimulation

Chunyan Qin; Zhilian Yue; Yunfeng Chao; Robert Forster; Fionn Maolmhuaidh; Xu-Feng Huang; Stephen Beirne; Gordon Wallace; Jun Chen

 

Australian Journal of Chemistry

On-Resin Strategy to Label α-Conotoxins: Cy5-RgIA, a Potent α9α10 Nicotinic Acetylcholine Receptor Imaging Probe

Markus Muttenthaler; Simon Nevin; Marco Inserra; Richard Lewis; David Adams; Paul Alewood  

 

Australian Journal of Chemistry

Barrierless Reactions of Three Benzonitrile Radical Cations with Ethylene

Oisin Shiels; Patrick Kelly; Stephen Blanksby; Gabriel da Silva; Adam Trevitt           

 

Behavioral Ecology and Sociobiology

Covariation in superoxide, sperm telomere length and sperm velocity in a polymorphic reptile

Christopher Friesen; Nicky Rollings; Mark Wilson; Camilla Whittington; Richard Shine; Mats Olsson

 

Biochemical Pharmacology

Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom

Karen Luna-Ramirez; Agota Csoti; Jeffrey McArthur; Yanni Chin; Raveendra Anangi; Rosby Najera; Lourival Possani; Glenn King; Gyorgy Panyi; Haibo Yu

 

Biomacromolecules

Distribution of Particles in Human Stem Cell-Derived 3D Neuronal Cell Models: Effect of Particle Size, Charge, and Density

Ewa Czuba-Wojnilowicz; Sara Miellet; Agata Glab; Serena Viventi; Francesca Cavalieri; Christina Cortez-Jugo; Mirella Dottori; Frank Caruso    

 

Biomolecules

Vascular epiphytic medicinal plants as sources of therapeutic agents: Their ethnopharmacological uses, chemical composition, and biological activities

Ari Nugraha; Bawon Triatmoko; Phurpa Wangchuk; Paul Keller

 

Biomolecules

Anti-cancer evaluation of depsides isolated from indonesian folious lichens: Physcia millegrana, parmelia dilatata and parmelia aurulenta

Ari Nugraha; Tinton Laksono; Lilla Firli; Chintya Sukrisno; Dwi Pratoko; Zulfikar Zulfikar; Ludmilla Untari; Hendris Wongso; Jacob Lambert; Carolyn Dillon 

 

Bioorganic and Medicinal Chemistry

α-Glucosidase inhibitory and nitric oxide production inhibitory activities of alkaloids isolated from a twig extract of Polyalthia cinnamomea

Virayu Suthiphasilp; Wisanu Maneerat; Narawadee Rujanapun; Thidarat Duangyod; Rawiwan Charoensup; Suwanna Deachathai; Raymond Andersen; Brian Patrick; Stephen Pyne; Surat Laphookhieo             

 

Bioorganic and Medicinal Chemistry

Design, synthesis and evaluation of carbamate-linked uridyl-based inhibitors of human ST6Gal I

Andrew Montgomery; Christopher Dobie; Remi Szabo; Laura Hallam; Marie Ranson; Haibo Yu; Danielle Skropeta

 

BMC Medical Ethics

Community perspectives on the benefits and risks of technologically enhanced communicable disease surveillance systems: A report on four community juries

Chris Degeling; Stacy Carter; Antoine van Oijen; Jeremy McAnulty; Vitali Sintchenko; Annette Braunack-Mayer; Trent Yarwood; Jane Johnson; Gwendolyn Gilbert        

 

BMC Pharmacology and Toxicology

Brown adipose tissue activity is modulated in olanzapine-treated young rats by simvastatin

Xuemei Liu; Xiyu Feng; Chao Deng; Lu Liu; Yanping Zeng; Chang Hu           

 

Brain Research Bulletin 

Differential susceptibility of human neural progenitors and neurons to ischaemic injury

Ye Liu; Anna Michalska; Mirella Dottori; Emma Eaton; Jo Courtney; Ana Antonic; David Howells

 

British Journal of Cancer

Insights into the role of sialylation in cancer progression and metastasis

Christopher Dobie; Danielle Skropeta

 

British Journal of Pharmacology

Fulditoxin, representing a new class of dimeric snake toxins, defines novel pharmacology at nicotinic ACh receptors

Chun Foo; Chacko Jobichen; Varuna Hassan-Puttaswamy; Zoltan Dekan; Han-Shen Tae; Daniel Bertrand; David Adams; Paul Alewood; J Sivaraman; Selvanayagam Nirthanan     

 

British Journal of Pharmacology

Pharmacological and genetic characterisation of the canine P2X4 receptor

Reece Sophocleous; Tracey Berg; Rocio Finol Urdaneta; Vanessa Sluyter; Shikara Keshiya; Lachlan Bell; Stephen Curtis; Belinda Curtis; Aine Seavers; Rachael Bartlett     

 

Cancers

Assessment of periprostatic and subcutaneous adipose tissue lipolysis and adipocyte size from men with localized prostate cancer

Dushan Miladinovic; Thomas Cusick; Kate Mahon; Anne Haynes; Colin Cortie; Barbara Meyer; Phillip Stricker; Gary Wittert; Lisa Butler; Lisa Horvath

 

Cancers

Breast tumor cell invasion and pro-invasive activity of cancer-associated fibroblasts co-targeted by novel urokinase-derived decapeptides   

Stefania Belli; Paola Franco; Francesca Iommelli; Anna De Vincenzo; Diego Brancaccio; Marialucia Telesca; Francesco Merlino; Ettore Novellino; Marie Ranson; Silvana Vecchio             

 

Cells

A Simple Differentiation Protocol for Generation of Induced Pluripotent Stem Cell-Derived Basal Forebrain-Like Cholinergic Neurons for Alzheimer's Disease and Frontotemporal Dementia Disease Modeling

Sonia Sanz Munoz; Martin Engel; Rachelle Balez; Phuong Dzung Do-Ha; Mauricio E Castro Cabral Da Silva; Damian Hernandez; Tracey Berg; Jennifer Fifita; Natalie Grima; Shu Yang

 

ChemElectroChem

Sensitive Detection of Motor Neuron Disease Derived Exosomal miRNA Using Electrocatalytic Activity of Gold-Loaded Superparamagnetic Ferric Oxide Nanocubes

Mostafa Masud; Rabbee Mahmudunnabi; Nahian Aziz; Claire Stevens; Phuong Dzung Do-Ha; Shu Yang; Ian Blair; Md Shahriar Hossain; Yoon Shim; Lezanne Ooi

 

Chemical Biology and Drug Design

Linear triazole-linked pseudo oligogalactosides as scaffolds for galectin inhibitor development

Christophe Dussouy; Chandan Kishor; Annie Lambert; Clément Lamoureux; Helen Blanchard; Cyrille Grandjean   

 

Chemical Communications

Second-order programming the synthesis of metal-organic frameworks 

Mitchell Fishburn; Dayne Skelton; Shane Telfer; Pawel Wagner; Christopher Richardson 

 

Chemical Communications

Mixed donor, phenanthroline photoactive MOFs with favourable CO<inf>2</inf>selectivity

Caitlin Setter; Michael Price; Luke Conte; Wolfgang Schmitt; Stuart Batten; Christopher Richardson; Matthew Hill; Ravichandar Babarao; Lauren MacReadie

 

Chemical Physics

Ab initio study on physical and chemical interactions at borates and iron oxide interface at high temperature

Huong Ta; A Tieu; Hongtao Zhu; Haibo Yu; Nam Tran; Bach Tran; Shanhong Wan; Thi Ta

 

Chemical Physics

Surface transformation and interactions of iron oxide in glassy lubricant: An ab initio study

Manh Ha Le; Anh Tieu; Hongtao Zhu; Thi Ta; Haibo Yu; Thi Thuy Huong Ta; V Tran              

 

Chemical Science

Rhodium-catalysed tetradehydro-Diels-Alder reactions of enediynes: Via a rhodium-stabilized cyclic allene

Srinivas Thadkapally; Kaveh Farshadfar; Melanie Drew; Christopher Richardson; Alireza Ariafard; Stephen Pyne; Christopher Hyland

 

Clinical Nutrition

Anthocyanins attenuate vascular and inflammatory responses to a high fat high energy meal challenge in overweight older adults: A cross-over, randomized, double-blind clinical trial

Vinicius do Rosario; Courtney Chang; Jaclyn Spencer; Thilani Alahakone; Steven Roodenrys; Monique Francois; Katrina Green; Nadine Holzel; David Nichols; Katherine Kent

 

Clinical Science

Increased P2X7 expression in the gastrointestinal tract and skin in a humanised mouse model of graft-versus-host disease

Peter Cuthbertson; Sam Adhikary; Nicholas Geraghty; Thomas Guy; Amirazin Hadjiashrafi; Stephen Fuller; Diane Ly; Debbie Watson; Ronald Sluyter 

 

CNS Neuroscience and Therapeutics

Risperidone stimulates food intake and induces body weight gain via the hypothalamic arcuate nucleus 5-HT2c receptor—NPY pathway

Xiao Wan; Fan Zeng; Xu-Feng Huang; He-Qin Yang; Lan Wang; Yan-Chuan Shi; Zhi-Hui Zhang; Shu Lin

 

CrystEngComm

A post-synthetically reduced borane-functionalised metal-organic framework with oxidation-inhibiting reactivity

Timothy Ablott; Shane Telfer; Christopher Richardson

 

Current Eye Research

Profiling and Bioinformatic Analysis of Differentially Expressed Cytokines in Aqueous Humor of High Myopic Eyes–Clues for Anti-VEGF Injections   

Xiangjia Zhu; Yu Du; Roger Truscott; Wenwen He; Peng Zhou; Yi Lu

 

Current Nutrition Reports

The Postprandial Effect of Anthocyanins on Cardiovascular Disease Risk Factors: a Systematic Literature Review of High-Fat Meal Challenge Studies

Vinicius do rosario; Jaclyn Spencer; Katrina Green; Karen Charlton

 

Current Opinion in Structural Biology

Polarisable force fields: what do they add in biomolecular simulations?

V Inakollu; Daan Geerke; Christopher Rowley; Haibo Yu 

 

Dalton Transactions

A new class of quadruplex DNA-binding nickel Schiff base complexes

Quynh Thai Son Pham; Nawal Assadawi; Jadon Wells; Reece Sophocleous; Kimberley Davis; Haibo Yu; Ronald Sluyter; Carolyn Dillon; Celine Kelso; Jennifer Beck

 

Dalton Transactions

Hypervalent organoiodine(v) metal-organic frameworks: Syntheses, thermal studies and stoichiometric oxidants

Macguire Bryant; Christopher Richardson             

 

Dalton Transactions: an international journal of inorganic chemistry

The effect of isomerism and other structural variations on the G-quadruplex DNA-binding properties of some nickel Schiff base complexes

Son Pham; Christopher Richardson; Celine Kelso; Anthony Willis; Stephen Ralph

 

Diabetes

Low-Dose Interleukin-2 Combined With Rapamycin Led to an Expansion of CD4+CD25+FOXP3+ Regulatory T Cells and Prolonged Human Islet Allograft Survival in Humanized Mice

Min Hu; Wayne Hawthorne; Leigh Nicholson; Heather Burns; Yi Qian; David Liuwantara; Elvira Jimenez; Yi Chew; Lindy Williams; Shounan Yi

 

Dyes and Pigments

Synthesis, structural/photophysical characterization and theoretical investigations with new β-pyridinium/quinolinium and β-bromine substituted bis(1,3-dimethylbarbituric acid) trimethine oxonol dyes that display large Stokes shifts

Fereshteh Azamifar; M Naimi-Jamal; Ardeshir Rineh; Michael Kelso

 

Education Sciences

Approaches to learning: Does medical school attract students with the motivation to go deeper?

Kylie Mansfield; Gregory Peoples; Lyndal Parker-Newlyn; Danielle Skropeta         

 

eLife

A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution

Bishnu Paudel; Aaron Moye; Hala Abou Assi; Roberto El-Khoury; Scott Cohen; Jessica Holien; Monica Birrento; Siritron Samosorn; Kamthorn Intharapichai; Christopher Tomlinson

 

eNeuro

More than a Corepressor: The Role of CoREST Proteins in Neurodevelopment

Simon Maksour; Lezanne Ooi; Mirella Dottori

 

European Journal of Nutrition

Association between flavonoid intake and risk of hypertension in two cohorts of Australian women: a longitudinal study

Vinicius do Rosario; Danielle Schoenaker; Katherine Kent; Katrina Green; Karen Charlton

 

European Journal of Pharmaceutics and Biopharmaceutics

N-acetyl-D-glucosamine-conjugated PAMAM dendrimers as dual receptor-targeting nanocarriers for anticancer drug delivery

Deep Pooja; T Srinivasa; Hitesh Kulhari; Amrita Kadari; David Adams; Vipul Bansal; Ramakrishna Sistla

 

European Journal of Taxonomy

Taxonomic revision of australian amobia robineau-desvoidy, 1830 (Sarcophagidae: Miltogramminae): Integrating morphology and genetics finds a new species and tackles old problems

Nikolas Johnston; James Wallman; Mark Dowton; Krzysztof Szpila; Thomas Pape

 

Frontiers in Cellular Neuroscience

Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises

Luke McAlary; Yee Lian Chew; Jeremy Lum; Nicholas Geraghty; Justin Yerbury; Neil Cashman       

 

Frontiers in Microbiology

Antibiotic-Induced Mutagenesis: Under the Microscope

Sarah Revitt-Mills; Andrew Robinson

 

Frontiers in Neuroscience

Curdlan Prevents the Cognitive Deficits Induced by a High-Fat Diet in Mice via the Gut-Brain Axis

Xiaoying Yang; Mingxuan Zheng; Shanshan Hao; Hongli Shi; Danhong Lin; Xi Chen; Alec Becvarovski; Wei Pan; Peng Zhang; Minmin Hu          

 

Frontiers in Neuroscience

Prevention of Neurite Spine Loss Induced by Dopamine D2 Receptor Overactivation in Striatal Neurons

Peng Zheng; Qian Su; Dayong Jin; Yinghua Yu; Xu-Feng Huang

 

Frontiers in Pharmacology

Use of Humanized Mouse Models to Investigate the Roles of Purinergic Signaling in Inflammation and Immunity 

Ronald Sluyter; Debbie Watson 

 

Frontiers in Plant Science

Latitudinal biogeographic structuring in the globally distributed moss Ceratodon purpureus

Elisabeth Biersma; Peter Convey; Rhys Wyber; Sharon Robinson; Mark Dowton; Bart Van De Vijver; Katrin Linse; Howard Griffiths; Jennifer Jackson

 

Frontiers in Psychiatry

The Role of Cathepsins in Memory Functions and the Pathophysiology of Psychiatric Disorders

Christine Niemeyer; Natalie Matosin; Dominic Kaul; Alexandra Philipsen; Nils Gassen

 

Gastroenterology

Human Plasminogen Exacerbates Clostridioides difficile Enteric Disease and Alters the Spore Surface

Milena Awad; Melanie Hutton; Adam Quek; William Klare; Steven Mileto; Kate Mackin; Diane Ly; Viola Oorschot; Marijana Bosnjak; Grant Jenkin 

 

Genes, Brain and Behavior

Novel behavioural characteristics of the superoxide dismutase 1 G93A (SOD1<sup>G93A</sup>) mouse model of amyotrophic lateral sclerosis include sex-dependent phenotypes

Fabian Kreilaus; Stefan Guerra; Rebecca Masanetz; Victoria Menne; Justin Yerbury; Tim Karl

 

Glia

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

Vandana Deora; John Lee; Eduardo Albornoz; Luke McAlary; Cyril Jagaraj; Avril Robertson; Julie Atkin; Matthew Cooper; Kate Schroder; Justin Yerbury

 

Green Chemistry

An environmentally sustainable biomimetic production of cyclic disulfide-rich peptides  

Kuok Yap; Junqiao Du; Fong Looi; Shyn Tang; Simon De Veer; Anuja Bony; Fabian Rehm; Jing Xie; Lai Chan; Conan Wang   

 

Immunology and Cell Biology

A single-nucleotide polymorphism in the human ENTPD1 gene encoding CD39 is associated with worsened graft-versus-host disease in a humanized mouse model

Sam Adhikary; Peter Cuthbertson; Ross Turner; Ronald Sluyter; Debbie Watson  

 

International Journal for Parasitology

Distinct adaptations of a gametocyte ABC transporter to murine and human Plasmodium parasites and its incompatibility in cross-species complementation

Sanketha Kenthirapalan; Phuong Tran; Taco Kooij; Melanie Ridgway; Manuel Rauch; Simon Brown; Todd Mitchell; Kai Matuschewski; Alexander Maier

 

International Journal of Mass Spectrometry

Protonation isomers of highly charged protein ions can be separated in FAIMS-MS

J Zhang; Micah Donor; Amber Rolland; Michael Leeming; Huixin Wang; Adam Trevitt; K Kabir; James Prell; William Donald 

 

International Journal of Molecular Sciences  

P2y<inf>2</inf> and p2x4 receptors mediate ca<sup>2+</sup> mobilization in dh82 canine macrophage cells

Reece Sophocleous; Nicole Miles; Lezanne Ooi; Ronald Sluyter

 

Iranian Journal of Basic Medical Sciences

Hypoglycemic activity of the ethyl acetate extract from Smilax glabra Roxb in mice: Biochemical and histopathological studies

Phuong Mai; Quang van Ngo; Minh Hong; Lien Quach; Stephen Pyne

 

Iranian Journal of Pharmaceutical Research

Characterization and antibacterial activity of phthalides from the roots of the mmedicinal herb levisticum officinale W.D.J. Koch

Mansour Miran; Hamidreza Monsef Esfahani; Jee Jung; Atousa Aliahmadi; Danielle Skropeta; Mahdi Abbas-Mohammadi; Samad Nejad Ebrahimi; Mahdi Farimani

 

iScience

Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS

Natalie Farrawell; Luke McAlary; Jeremy Lum; Christen Chisholm; Sadaf Warraich; Ian Blair; Kara Perrow; Darren Saunders; Justin Yerbury              

 

IUBMB Life

Half a century of bacteriophage lambda recombinase: In vitro studies of lambda exonuclease and Red-beta annealase

Jodi Brewster; Gokhan Tolun

 

Journal of Antimicrobial Chemotherapy

Cephalosporin nitric oxide-donor prodrug DEA-C3D disperses biofilms formed by clinical cystic fibrosis isolates of Pseudomonas aeruginosa

Odel Soren; Ardeshir Rineh; Diogo Silva; Yuming Cai; Robert Howlin; Raymond Allan; Martin Feelisch; Jane Davies; Gary Connett; Saul Faust

 

Journal of Applied Physics

Non-zero spontaneous magnetic moment along crystalline b-axis for rare earth orthoferrites 

Mohanad  Mohammed; Z Cheng; Shixun Cao; K Rule; C Richardson; A Edwards; A Studer; J Horvat

 

Journal of Biological Chemistry 

N- and C-terminal regions of αB-crystallin and Hsp27 mediate inhibition of amyloid nucleation, fibril binding, and fibril disaggregation 

Emily Selig; Courtney Zlatic; Dezerae Cox; Yee-Foong Mok; Paul Gooley; Heath Ecroyd; Michael Griffin

 

Journal of Biological Inorganic Chemistry

A study of Pt(II)–phenanthroline complex interactions with double-stranded and G-quadruplex DNA by ESI–MS, circular dichroism, and computational docking   

Dale Ang; Celine Kelso; Jennifer Beck; Stephen Ralph; David Harman; Janice Aldrich-Wright           

 

Journal of Biomolecular Structure and Dynamics

Molecular networking based dereplication of AChE inhibitory compounds from the medicinal plant Vincetoxicum funebre (Boiss. &amp; Kotschy)

Mahdi Abbas-Mohammadi; Mahdi Moridi; Peyman Salehi; Samad Ebrahimi; Ali Sonboli; Celine Kelso; Danielle Skropeta

 

Journal of Cell Science

Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells

Rebecca San Gil; Dezerae Cox; Luke McAlary; Tracey Berg; Adam Walker; Justin Yerbury; Lezanne Ooi; Heath Ecroyd

 

Journal of Chemical Ecology

Major Transitions in Cuticular Hydrocarbon Expression Coincide with Sexual Maturity in a Blowfly (Diptera: Calliphoridae)

Nathan Butterworth; Falko Drijfhout; Phillip Byrne; Paul Keller; James Wallman

 

Journal of Clinical Endocrinology and Metabolism

Maternal adipose tissue expansion, a missing link in the prediction of birth weight centile

Eleanor Jarvie; Frances Stewart; Jane Ramsay; E Brown; Barbara Meyer; Gunilla Olivecrona; Bruce Griffin; Dilys Freeman

 

Journal of Computational Chemistry

Atomistic Insights into Photoprotein Formation: Computational Prediction of the Properties of Coelenterazine and Oxygen Binding in Obelin

Thomas Griffiths; Aaron Oakley; Haibo Yu

 

Journal of Evolutionary Biology 

The evolution of sexually dimorphic cuticular hydrocarbons in blowflies (Diptera: Calliphoridae)

Nathan Butterworth; James Wallman; Falko Drijfhout; Nikolas Johnston; Paul Keller; Phillip Byrne

 

Journal of Materials Chemistry B

Development of CeO2 nanodot encrusted TiO2 nanoparticles with reduced photocatalytic activity and increased biocompatibility towards a human keratinocyte cell line

Alexander Morlando; Marcela Chaki Borras; Yaser Rehman; Shahnaz Bakand; Philip Barker; Ronald Sluyter; Konstantin Konstantinov

 

Journal of Materials Chemistry B

Coaxial mussel-inspired biofibers: Making of a robust and efficacious depot for cancer drug delivery

Sepehr Talebian; In Shim; Song Kim; Geoffrey Spinks; Kara Vine; Javad Foroughi

 

Journal of Medicinal Chemistry

Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action

Mohamed Metwaly; Wagdy Eldehna; Silvia Bua; Cecilia Lanzi; Laura Lucarini; Emanuela Masini; Thomas Peat; Hatem Abdel-Aziz; Alessio Nocentini; Paul Keller

 

Journal of Medicinal Chemistry

Dimerization of α-Conotoxins as a strategy to enhance the inhibition of the human α7 and α9α10 nicotinic acetylcholine receptors

Jiazhen Liang; Han-Shen Tae; Xiaoxiao Xu; Tao Jiang; David Adams; Rilei Yu           

 

Journal of Medicinal Chemistry

Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors

Yiyue Xie; Padmaja Tummala; Aaron Oakley; Girdhar Deora; Yuji Nakano; Melissa Rooke; Matthew Cuellar; Jessica Strasser; Jayme Dahlin; Michael Walters

 

Journal of Medicinal Chemistry

Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors

Yiyue Xie; Padmaja Tummala; Aaron Oakley; Girdhar Deora; Yuji Nakano; Melissa Rooke; Matthew Cuellar; Jessica Strasser; Jayme Dahlin; Michael Walters

 

Journal of Medicinal Chemistry

Rational Design and Synthesis of Methyl-β-d-galactomalonyl Phenyl Esters as Potent Galectin-8N Antagonists

Brijesh Patel; Chandan Kishor; Todd Houston; Hadas Shatz-Azoulay; Yehiel Zick; Yaron Vinik; Helen Blanchard

 

Journal of Neuroinflammation

Supplement of microbiota-accessible carbohydrates prevents neuroinflammation and cognitive decline by improving the gut microbiota-brain axis in diet-induced obese mice

Hongli Shi; Qiao Wang; Mingxuan Zheng; Shanshan Hao; Jeremy Lum; Xi Chen; Xu-Feng Huang; Yinghua Yu; Kuiyang Zheng  

 

Journal of Neuroscience

NPY/NPF-Related Neuropeptide FLP-34 Signals from Serotonergic Neurons to Modulate Aversive Olfactory Learning in Caenorhabditis elegans

Melissa Fadda; Nathan De Fruyt; Charline Borghgraef; Jan Watteyne; Katleen Peymen; Elke Vandewyer; Francisco Naranjo Galindo; Amanda Kieswetter; Olivier Mirabeau; Yee Lian Chew  

 

Journal of Photochemistry and Photobiology B: Biology

Y<inf>2</inf>O<inf>3</inf> decorated TiO<inf>2</inf> nanoparticles: Enhanced UV attenuation and suppressed photocatalytic activity with promise for cosmetic and sunscreen applications        Marcela

Chaki Borras; Ronald Sluyter; Philip Barker; Konstantin Konstantinov; Shahnaz Bakand

 

Journal of Physical Organic Chemistry

Predicting phosphirane air stability using density functional theory

Jayden Gaston; Patrick McCosker; Haibo Yu; Paul Keller 

 

Journal of Psychiatric Research

A synergistic effect between family intervention and rTMS improves cognitive and negative symptoms in schizophrenia: A randomized controlled trial

Xue Li; Xiuxia Yuan; Yulin Kang; Lijuan Pang; Yafei Liu; Qiyue Zhu; Luxian Lv; Xu-Feng Huang; Xueqin Song

 

Journal of Psychiatric Research

Decreased serum NCAM is positively correlated with hippocampal volumes and negatively correlated with positive symptoms in first-episode schizophrenia patients

Huimei An; Jun Qin; Hongzhen Fan; Fengmei Fan; Shuping Tan; Zhiren Wang; Jing Shi; Fude Yang; Yunlong Tan; Xu-Feng Huang       

 

Journal of Renal Nutrition

Safety and Efficacy of Using Nuts to Improve Bowel Health in Hemodialysis Patients

Kelly Lambert; Luke Bird; Addison Borst; Andrew Fuller; Yanan Wang; Geraint Rogers; Jordan Stanford; Martina Sanderson-Smith; Jonathan Williams; Brett McWhinney

 

Journal of the American Chemical Society

Genetic Encoding of para-Pentafluorosulfanyl Phenylalanine: A Highly Hydrophobic and Strongly Electronegative Group for Stable Protein Interactions

Haocheng Qianzhu; Adarshi Welegedara; Holly Williamson; Amy McGrath; Mithun Mahawaththa; Nicholas Dixon; Gottfried Otting; Thomas Huber

 

Life Sciences

DHA reduces hypothalamic inflammation and improves central leptin signaling in mice

Licai Cheng; Tao Hu; Hongli Shi; Xi Chen; Hongqin Wang; Kuiyang Zheng; Xu-Feng Huang; Yinghua Yu

 

Marine drugs

Interactions of the α3β2 Nicotinic Acetylcholine Receptor Interfaces with α-Conotoxin LsIA and its Carboxylated C-terminus Analogue: Molecular Dynamics Simulations

Jierong Wen; David Adams; Andrew Hung

 

Methods in Molecular Biology

Investigation of Group A Streptococcal Interactions with Host Glycan Structures Using High-Throughput Techniques: Glycan Microarray Analysis Using Recombinant Protein and Whole Cells 

Anuk Indraratna; David De Oliveira; Lauren Hartley-Tassell; Christopher Day; Mark Walker; Michael Jennings; Martina Sanderson-Smith

 

Microbiome

β-glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice

Hongli Shi; Yinghua Yu; Danhong Lin; Peng Zheng; Peng Zhang; Minmin Hu; Qiao Wang; Wei Pan; Xiaoying Yang; Tao Hu

 

Molecular Cell

Tunability of DNA Polymerase Stability during Eukaryotic DNA Replication

Jacob Lewis; Lisanne Spenkelink; Grant Schauer; Olga Yurieva; Stefan Mueller; Varsha Natarajan; Gurleen Kaur; Claire Maher; Callum Kay; Michael O'Donnell  

 

Molecular Cell

A Primase-Induced Conformational Switch Controls the Stability of the Bacterial Replisome

Enrico Monachino; Slobodan Jergic; Jacob Lewis; Zhi-Qiang Xu; Allen Lo; Valerie O'Shea; James Berger; Nicholas Dixon; Antonius van Oijen         

 

Molecular Imaging and Biology

Experimental and Data Analysis Considerations for Three-Dimensional Mass Spectrometry Imaging in Biomedical Research

D Vos; S Ellis; B Balluff; R Heeren              

 

mSphere

Analysis of Global Collection of Group A Streptococcus Genomes Reveals that the Majority Encode a Trio of M and M-Like Proteins

Hannah Frost; Mark Davies; Valerie Delforge; Dalila Lakhloufi; Martina Sanderson-Smith; Velusamy Srinivasan; Andrew Steer; Mark Walker; Bernard Beall; Anne Botteaux

 

Natural Product Research

Cytotoxic and larvicidal activities of Stemona alkaloids from the aerial parts and roots of Stemona curtisii Hook.f.

Sirinrat Chalom; Jukreera Panyakaew; Manlika Phaya; Stephen Pyne; Pitchaya Mungkornasawakul

 

Natural Product Research

A new secoiridoid glycoside and other constituents from the roots and flowers of Fagraea fragrans Roxb. (Gentianaceae)

Watchara Sangsopha; Ratsami Lekphrom; Florian Schevenels; Brendan Byatt; Stephen Pyne; Nattakarn Sridadom; Kanlayanee Sawanyawisuth

 

Natural Products Journal

α-Glucosidase Inhibitory Activity of the Extracts and Major Phytochemical Components of Smilax glabra Roxb

Phuong Nguyen; Quang Ngo; Minh Hue Nguyen; Alan Maccarone; Stephen Pyne

 

Nature 

Selective loading and processing of prespacers for precise CRISPR adaptation

Sungchul Kim; Luuk Loeff; Sabina Colombo; Slobodan Jergic; Stan Brouns; Chirlmin Joo

 

Nature communications

Single-molecule imaging reveals molecular coupling between transcription and DNA repair machinery in live cells

Han Ho; Antonius van Oijen; Harshad Ghodke

 

Nature Communications

Single-molecule live-cell imaging visualizes parallel pathways of prokaryotic nucleotide excision repair

Harshad Ghodke; Han Ho; Antonius van Oijen

 

Nature Communications

CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation

Yichen Zhong; Bishnu Paudel; Daniel Ryan; Jason Low; Charlotte Franck; Karishma Patel; Max Bedward; Mario Torrado; Richard Payne; Antoine van Oijen            

 

Nature Communications

Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes

Stephan Brouwer; Timothy Barnett; Diane Ly; Katherine Kasper; David De Oliveira; Tania Rivera-Hernandez; Amanda Cork; Liam McIntyre; Magnus Jespersen; Johanna Richter

 

Neuropharmacology

Ketamine inhibits synaptic transmission and nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglia in situ

Alexander Harper; Katrina Rimmer; Jhansi Dyavanapalli; Jeffrey McArthur; David Adams

 

Neuroscientist 

If Human Brain Organoids Are the Answer to Understanding Dementia, What Are the Questions?

Lezanne Ooi; Mirella Dottori; Anthony Cook; Martin Engel; Vini Gautam; Alexandra Grubman; Damián Hernández; Anna King; Simon Maksour; Helena Targa Dias Anastacio

 

Nucleic Acids Research

Resolving Toxic DNA repair intermediates in every E. coli replication cycle: critical roles for RecG, Uup and RadD  

Zachary Romero; Stefanie Chen; Thomas Armstrong; Elizabeth Wood; Antonius van Oijen; Andrew Robinson; Michael Cox

 

Nucleic Acids Research

Single-molecule live-cell imaging reveals RecB-dependent function of DNA polymerase IV in double strand break repair

Sarah Henrikus; Camille Henry; Amy McGrath; Slobodan Jergic; John McDonald; Yvonne Hellmich; Steven Bruckbauer; Matthew Ritger; Megan Cherry; Elizabeth Wood

 

Nucleic acids research

Frequent template switching in postreplication gaps: suppression of deleterious consequences by the Escherichia coli Uup and RadD proteins

Zachary Romero; Thomas Armstrong; Sarah Henrikus; Stefanie Chen; David Glass; Alexander Ferrazzoli; Elizabeth Wood; Sindhu Chitteni-Pattu; Antonius van Oijen; Susan Lovett 

 

Nucleic acids research

Development of a single-stranded DNA-binding protein fluorescent fusion toolbox

Katarzyna Dubiel; Camille Henry; Lisanne Spenkelink; Alexander Kozlov; Elizabeth Wood; Slobodan Jergic; Nicholas Dixon; Antonius van Oijen; Michael Cox; Timothy Lohman

 

Nutrients

Inflammation (Il-1β) modifies the effect of vitamin d and omega-3 long chain polyunsaturated fatty acids on core symptoms of autism spectrum disorder—an exploratory pilot study

Hajar Mazahery; Cathryn Conlon; Kathryn Beck; Owen Mugridge; Marlena Kruger; Welma Stonehouse; Carlos Camargo; Barbara Meyer; Bobby Tsang; Pamela von Hurst

 

Nutrients

High Variability in Erythrocyte, Plasma and Whole Blood EPA and DHA Levels in Response to Supplementation

Cassandra Sparkes; Andrew Sinclair; Robert Gibson; Paul Else; Barbara Meyer

 

Nutrients

The effect of dietary supplementation on aggressive behaviour in australian adult male prisoners: A feasibility and pilot study for a randomised, double blind placebo controlled trial

Colin Cortie; Mitchell Byrne; Carole Collier; Natalie Parletta; Donna Crawford; Pia Winberg; David Webster; Karen Chapman; Gayle Thomas; Jean Dally

 

Nutrients

Effect of omega-3 long chain polyunsaturated fatty acids (N-3 LCPUFA) supplementation on cognition in children and adolescents: A systematic literature review with a focus on n-3 LCPUFA blood values and dose of DHA and EPA

Inge van der Wurff; Barbara Meyer; Renate de Groot

 

Nutrition

Stunting is a recognised problem: evidence for the potential benefits of omega-3 long chain polyunsaturated fatty acids

Setyaningrum Rahmawaty; Barbara Meyer          

 

Organic and Biomolecular Chemistry

Five-membered cyclic sulfamidate imines: versatile scaffolds for organic synthesis

Quoc Hoang Pham; Christopher Hyland; Stephen Pyne

 

Pharmaceutical Sciences

Antibacterial Components of Levisticum officinale Koch Against Multidrug-resistant Mycobacterium tuberculosis

Hamidreza Esfahani; Mahdi Moridi Farimani; Samad Nejad Ebrahimi; Jee Hyung Jung; Atousa Aliahmadi; Mahdi Abbas-Mohammadi; Danielle Skropeta; Hossein Kazemian; Mohammadmehdi Feizabadi; Mansour Miran             

 

Pharmaceutics 

N-alkylisatin-loaded liposomes target the urokinase plasminogen activator system in breast cancer

Lisa Belfiore; Darren Saunders; Marie Ranson; Kara Perrow

 

Pharmacological Research

Epigenetic histone modulations of PPARγ and related pathways contribute to olanzapine-induced metabolic disorders

Yueqing Su; Xuemei Liu; Jiamei Lian; Chao Deng

 

Pharmacology Biochemistry and Behavior

The dosage-dependent effects of cevimeline in preventing olanzapine-induced metabolic side-effects in female rats

Jiamei Lian; Chao Deng 

 

Pharmacology Biochemistry and Behavior

Exercise intervention for preventing risperidone-induced dyslipidemia and gluco-metabolic disorders in female juvenile rats

Emma Sylvester; Weijie Yi; Mei Han; Chao Deng

 

Physical Chemistry Chemical Physics

Reactions of a distonic peroxyl radical anion influenced by SOMO-HOMO conversion: an example of anion-directed channel switching

Sui So; Benjamin Kirk; Uta Wille; Adam Trevitt; Stephen Blanksby; Gabriel da Silva

 

Physical Chemistry Chemical Physics

Gas phase reactions of iodide and bromide anions with ozone: evidence for stepwise and reversible reactions

Mahendra Bhujel; David Marshall; Alan Maccarone; Benjamin McKinnon; Adam Trevitt; Gabriel da Silva; Stephen Blanksby; Berwyck Poad

 

Phytochemistry

Styryllactones from Goniothalamus tamirensis

Pornphimol Meesakul; Wuttichai Jaidee; Christopher Richardson; Raymond Andersen; Brian Patrick; Anthony Willis; Chatchai Muanprasat; Jin Wang; Xiaoguang Lei; Sarinya Hadsadee

 

Phytochemistry

Isolation of CFTR and TMEM16A inhibitors from Neorautanenia mitis (A. Rich) Verdcourt: Potential lead compounds for treatment of secretory diarrhea

Christiana Dawurung; Rattikarn Noitem; Roonglawan Rattanajak; Ratchanu Bunyong; Christopher Richardson; Anthony Willis; Sumalee Kamchonwongpaisan; Chantapol Yimnual; Chatchai Muanprasat; Stephen Pyne 

 

PloS one

Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

Anthony Crown; Luke McAlary; Eric Fagerli; Hilda Brown; Justin Yerbury; Ahmad Galaleldeen; Neil Cashman; David Borchelt; Jacob Ayers

 

Progress in Neuro-Psychopharmacology and Biological Psychiatry

The Wistar-Kyoto rat model of endogenous depression: A tool for exploring treatment resistance with an urgent need to focus on sex differences

Samuel Millard; Katrina Weston-Green; Kelly Newell

Prostaglandins Leukotrienes and Essential Fatty Acids

ISSFAL Official Statement Number 6: The importance of measuring blood omega-3 long chain polyunsaturated fatty acid levels in research   

Renate de Groot; Barbara Meyer

 

Psychiatry Research

The correlation between metabolic syndrome and neurocognitive and social cognitive performance of patients with schizophrenia

Shengyun Chen; Xiaowei Xia; Chao Deng; Xiuhua Wu; Zili Han; Jiong Tao; Xiaoli Wu

 

Psychoneuroendocrinology

Olanzapine increases AMPK-NPY orexigenic signaling by disrupting H1R-GHSR1a interaction in the hypothalamic neurons of mice

Xiaoqi Chen; Yinghua Yu; Peng Zheng; Tiantian Jin; Meng He; Mingxuan Zheng; Xueqin Song; Alison Jones; Xu-Feng Huang

 

Purinergic Signalling

The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1<sup>G93A</sup> mice

Diane Ly; Anjila Dongol; Peter Cuthbertson; Thomas Guy; Nicholas Geraghty; Reece Sophocleous; Lucia Sin; Bradley Turner; Debbie Watson; Justin Yerbury

 

Purinergic Signalling

Comparison of peripheral blood mononuclear cell isolation techniques and the impact of cryopreservation on human lymphocytes expressing CD39 and CD73

Ross Turner; Nicholas Geraghty; Jonathan Williams; Diane Ly; Daniel Brungs; Martin Carolan; Thomas Guy; Debbie Watson; Jeremiah de Leon; Ronald Sluyter

 

Rapid Communications in Mass Spectrometry

Structural elucidation of hydroxy fatty acids by photodissociation mass spectrometry with photolabile derivatives

Venkateswara Narreddula; Pawel Sadowski; Nathan Boase; David Marshall; Berwyck Poad; Adam Trevitt; Todd Mitchell; Stephen Blanksby        

 

Royal Society Open Science

Telomere length varies substantially between blood cell types in a reptile: Telomere length in different blood cells

Mats Olsson; Nicholas Geraghty; Erik Wapstra; Mark Wilson

 

RSC Advances

Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-a] pyrimidines as potential anti-chikungunya agents

Mohamed Metwaly; Patrick McCosker; Muhammad Alsherbiny; Anthony Willis; Timothy Clark; Johan Neyts; Dirk Jochmans; Paul Keller    

 

Scientific Reports

Establishment of novel long-term cultures from EpCAM positive and negative circulating tumour cells from patients with metastatic gastroesophageal cancer

Daniel Brungs; Elahe Minaei; Ann-Katrin Piper; Jay Perry; Ashleigh Splitt; Martin Carolan; Shantay Ryan; Xiao Wu; Stephanie Corde Tehei; Moeava Tehei

 

Scientific Reports

Rapid high-yield expression and purification of fully post-translationally modified recombinant clusterin and mutants

Sandeep Satapathy; Rebecca Dabbs; Mark Wilson             

 

Scientific Reports

N-acetylcysteine prevents olanzapine-induced oxidative stress in mHypoA-59 hypothalamic neurons

Zehra Boz; Minmin Hu; Yinghua Yu; Xu-Feng Huang

 

Small

Multimodal Stimulation in a Microfluidic Device Facilitates Studies of Interneurons in Sensory Integration in C. elegans

Yongmin Cho; Sol Lee; Yee Chew; Kirby Broderick; William Schafer; Hang Lu

 

Stem Cell Research

The mRNA-based reprogramming of fibroblasts from a SOD1<sup>E101G</sup> familial amyotrophic lateral sclerosis patient to induced pluripotent stem cell line UOWi007   

Rachelle Balez; Tracey Berg; Monique Bax; Sonia Sanz Munoz; Mauricio E Castro Cabral Da Silva; Martin Engel; Phuong Dzung Do-Ha; Claire Stevens; Dominic Rowe; Shu Yang   

 

Synlett 

Palladium-Catalyzed Decarboxylative Formal (4 + 2) Cycloaddition of Vinyl Benzoxazinanones with 3-Nitroindoles

Melissa Bird; Steven Wales; Christopher Richardson; Christopher Hyland

 

Synthetic Communications

Synthesis of thioridazine-VLA-4 antagonist hybrids using N-propargyl northioridazine enantiomers

Alexander Martyn; Anthony Willis; Michael Kelso             

 

Tetrahedron Letters

Intramolecular interception of the Newman-Kwart rearrangement by carboxylic acids

Timothy Ablott; Mitchell Fishburn; David Turner; Christopher Richardson              

 

The Conversation

Early and mid-career scientists face a bleak future in the wake of the pandemic  

Justine Shaw; Yee Lian Chew

 

The Journal of Antibiotics

Assessing the role of pharyngeal cell surface glycans in group a streptococcus biofilm formation 

Heema Vyas; Anuk Indraratna; Arun Everest-Dass; Nicolle Packer; David De Oliveira; Marie Ranson; Jason McArthur; Martina Sanderson-Smith

 

The Journal of experimental medicine

Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain

Jeroen Bogie; Elien Grajchen; Elien Wouters; Aida Corrales; Tess Dierckx; Sam Vanherle; Jo Mailleux; Pascal Gervois; Esther Wolfs; Jonas Dehairs

 

The Journal of Physical Chemistry A: Isolated Molecules, Clusters, Radicals, and Ions; Environmental Chemistry, Geochemistry, and Astrochemistry; Theory

Exploration of the Dehydrogenation Pathways of Ammonia Diborane and Diammoniate of Diborane by Molecular Dynamics Simulations Using Reactive Force Fields

Peng Gao; Zhenguo Huang; Haibo Yu

 

The Journal of Physical Chemistry A: Isolated Molecules, Clusters, Radicals, and Ions; Environmental Chemistry, Geochemistry, and Astrochemistry; Theory

Perylene-Monoimides: Singlet Fission Down-Conversion Competes with Up-Conversion by Geminate Triplet-Triplet Recombination

Ilias Papadopoulos; David Gutierrez-Moreno; Patrick McCosker; Ruben Casillas; Paul Keller; Angela Sastre-Santos; Timothy Clark; Fernando Fernandez-Lazaro; Dirk Guldi   

 

The journal of physical chemistry letters

Discrimination between Protonation Isomers of Quinazoline by Ion Mobility and UV-Photodissociation Action Spectroscopy

Samuel Marlton; Benjamin McKinnon; Boris Ucur; James Bezzina; Stephen Blanksby; Adam Trevitt

 

Transplantation

Indirectly Activated Treg Allow Dominant Tolerance to Murine Skin-grafts Across an MHC Class I Mismatch After a Single Donor-specific Transfusion

Geoff Zhang; Min Hu; Debbie Watson; Yuan Min Wang; John Knight; Stephen Alexander

 

Trends in Neurosciences

Proteome Homeostasis Dysfunction: A Unifying Principle in ALS Pathogenesis

Justin Yerbury; Natalie Farrawell; Luke McAlary 

 

Encyclopedia of Gerontology and Population Aging

Health 3.0

Ping Yu; Chao Deng

 

Recent Advances in Cannabinoid Research

The United Chemicals of Cannabis: Beneficial Effects of Cannabis Phytochemicals on the Brain and Cognition

Katrina Weston-Green 

 

ACS Applied Materials and Interfaces

Theoretical Investigation on The Single Transition-Metal Atom-Decorated Defective MoS2 for Electrocatalytic Ammonia Synthesis

Haoran Guo; Lei Li; Xingyong Wang; Ge Yao; Haibo Yu; Ziqi Tian; Baihai Li; Liang Chen

 

ACS Chemical Neuroscience

CuATSM Protects Against the in Vitro Cytotoxicity of Wild-Type-Like Copper-Zinc Superoxide Dismutase Mutants but not Mutants That Disrupt Metal Binding

Natalie Farrawell; Maddison Yerbury; Steven Plotkin; Luke McAlary; Justin Yerbury

 

ACS Chemical Neuroscience

Tacrine-Hydrogen Sulfide Donor Hybrid Ameliorates Cognitive Impairment in the Aluminum Chloride Mouse Model of Alzheimer's Disease

Xiao-jing Cheng; Jing-xue Gu; Yi-peng Pang; Jiao Liu; Ting Xu; Xin-rui Li; Yu-zhou Hua; Kelly Newell; Xu-Feng Huang; Yinghua Yu         

 

ACS Chemical Neuroscience

α-Conotoxin Vc1.1 structure-activity relationship at the human α9α10 nicotinic acetylcholine receptor investigated by minimal side chain replacement

Xin Chu; Han-Shen Tae; Qingliang Xu; Tao Jiang; David Adams; Rilei Yu

 

ACS Omega

11B NMR Chemical Shift Predictions via Density Functional Theory and Gauge-Including Atomic Orbital Approach: Applications to Structural Elucidations of Boron-Containing Molecules

Peng Gao; Xingyong Wang; Zhenguo Huang; Haibo Yu     

 

Acta Neuropathologica Communications

Apolipoprotein E and clusterin inhibit the early phase of amyloid-β aggregation in an in vitro model of cerebral amyloid angiopathy

Yoshinori Endo; Kazuhiro Hasegawa; Ryo Nomura; Hidetaka Arishima; Ken-ichiro Kikuta; Taro Yamashita; Yasuteru Inoue; Mitsuharu Ueda; Yukio Ando; Mark Wilson            

 

Acta Pharmacologica Sinica

Simvastatin improves olanzapine-induced dyslipidemia in rats through inhibiting hepatic mTOR signaling pathway

Xue-mei Liu; Xiao-min Zhao; Chao Deng; Yan-ping Zeng; Chang-Hua Hu

 

Advanced Theory and Simulations

Towards an Accurate Prediction of Nitrogen Chemical Shifts by Density Functional Theory and Gauge-Including Atomic Orbital 

Peng Gao; Xingyong Wang; Haibo Yu

 

Analytical Chemistry

Introduction of a Fixed-Charge, Photolabile Derivative for Enhanced Structural Elucidation of Fatty Acids

Venkateswara Narreddula; Nathan Boase; Ramesh Ailuri; David Marshall; Berwyck Poad; Michael Kelso; Adam Trevitt; Todd Mitchell; Stephen Blanksby             

 

Analytical Chemistry

Enhanced Sensitivity Using MALDI Imaging Coupled with Laser Postionization (MALDI-2) for Pharmaceutical Research

Florian Barre; Martin Paine; Bryn Flinders; Adam Trevitt; Patrick Kelly; Rima Ait-Belkacem; Joao Garcia; Laura Creemers; Jonathan Stauber; Rob Vreeken

 

Analytical Chemistry

Rapid Identification of Ischemic Injury in Renal Tissue by Mass-Spectrometry Imaging

T Van Smaalen; Shane Ellis; N Mascini; T Siegel; Berta Cillero-Pastor; L Hillen; L Van Heurn; C Peutz-Kootstra; Ron Heeren

 

Angewandte Chemie - International Edition

Reshaping Lipid Biochemistry by Pushing Barriers in Structural Lipidomics

Tiffany Porta Siegel; Kim Ekroos; Shane Ellis

 

Angewandte Chemie International Edition

Dual Gold‐Catalyzed Cycloaromatization of Unconjugated (E)‐Enediynes

Farzad Zamani; Rasool Babaahmadi; Brian Yates; Michael Gardiner; Alireza Ariafard; Stephen Pyne; Christopher Hyland

 

ANZ Journal of Surgery 

Carbapenem sparing in the management of post-transrectal prostate biopsy bacteraemia

Mohamad-Ali Trad; Mishael Materne; Gemma Reynolds; Jinna Yao; Spyridon Miyakis; Timothy Skyring; Peter Newton

 

Asia-Pacific Journal of Clinical Oncology

First-in-human phase I study of infusional and bolus schedules of Deflexifol, a novel 5-fluorouracil and leucovorin formulation, after failure of standard treatment

Phillip Clingan; Stephen Ackland; Daniel Brungs; Paul de Souza; Morteza Aghmesheh; Madhu Garg; Richard Ranson; Suzanne Parker; Rebecca Jokela; Marie Ranson  

 

Austral Ecology

High tolerance of repeated heatwaves in Australian native plants

Kris French; Isaac Jansens; Michael Ashcroft; Heath Ecroyd; Sharon Robinson

 

 

Australian Journal of Chemistry: an international journal for chemical science

The Elusive Nitro-Functionalised Member of the IRMOF-9 Family

Luke Conte; Tian-You Zhou; Omid Qazvini; Lujia Liu; David Turner; Shane Telfer; Christopher Richardson 

 

BBA: Proteins and Proteomics

Cleavage C-terminal to Asp leads to covalent crosslinking of long-lived human proteins

Zhen Wang; Michael Friedrich; Roger Truscott; Kevin Schey

 

Biochemical Journal

Mechanism of protein cleavage at asparagine leading to protein-protein cross-links

Michael Friedrich; Zhen Wang; Kevin Schey; Roger Truscott

 

Biochemistry

Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis

Janice Ng; Maya Hanspal; Naunehal Matharu; Teresa Barros; Elin Esbjorner; Mark Wilson; Justin Yerbury; Christopher Dobson; Janet Kumita

 

Bioorganic and Medicinal Chemistry Letters

Prototyping kinase inhibitor-cytotoxin anticancer mutual prodrugs activated by tumour hypoxia: A chemical proof of concept study

Geraud Sansom; Nicholas Kirk; Christopher Guise; Robert Anderson; Jeff Smaill; Adam Patterson; Michael Kelso

 

Bioorganic and Medicinal Chemistry Letters

6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease

Benjamin Buckley; Hiwa Majed; Ashraf Aboelela; Elahe Minaei; Longguang Jiang; Karen Fildes; Chen-Yi Cheung; Darren Johnson; Daniel Bachovchin; Gregory Cook

 

Biophysical Journal

Identification of Multiple Kinetic Populations of DNA-Binding Proteins in Live Cells

Han Ho; Daniel Zalami; Jurgen Kohler; Antonius van Oijen; Harshad Ghodke

 

Biophysical Reviews

When proteins play tag: the dynamic nature of the replisome

Stefan Mueller; Lisanne Spenkelink; Antoine van Oijen

 

BMC Public Health

The drivers of antibiotic use and misuse: the development and investigation of a theory driven community measure

Mitchell Byrne; Sebastien Miellet; Anica McGlinn; Janaye Fish; Shahla Meedya; Nina Reynolds; Antonius van Oijen

BMJ Open

Multifaceted intervention to enhance cognition in older people at risk of cognitive decline: Study protocol for the Protein Omega-3 and Vitamin D Exercise Research (PONDER) study

Helen Macpherson; Sarah Brownell; Rachel Duckham; Barbara Meyer; Sam Mirzaee; Robin Daly 

 

Brain, Behavior, and Immunit

Cannabidiol improves behavioural and neurochemical deficits in adult female offspring of the maternal immune activation (poly I:C) model of neurodevelopmental disorders

Ashleigh Osborne; Nadia Solowij; Ilijana Babic; Jeremy Lum; Xu-Feng Huang; Kelly Newell; Katrina Weston-Green

 

British Journal of Nutrition

Non-dietary factors associated with n-3 long chain PUFA levels in humans - a systematic literature review

Renate de Groot; Rebecca Emmett; Barbara Meyer         

 

British Journal of Pharmacology

Analgesic transient receptor potential vanilloid-1-active compounds inhibit native and recombinant T-type calcium channels

Jeffrey McArthur; Rocio Finol-Urdaneta; David Adams

 

British Journal of Pharmacology

Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor

Rilei Yu; Han-Shen Tae; Qingliang Xu; David Craik; David Adams; Tao Jiang; Quentin Kaas

 

Catalysis Science and Technology

Proton supplier role of binuclear gold complexes in promoting hydrofunctionalisation of nonactivated alkenes

Maryam Asgari; Christopher Hyland; A. Stephen Hashmi; Brian Yates; Alireza Ariafard

 

Cell Death and Disease 

Dynamic interplay between H-current and M-current controls motoneuron hyperexcitability in amyotrophic lateral sclerosis

Yossi Buskila; Orsolya Kekesi; Alba Bellot-Saez; Winston Seah; Tracey Berg; Michael Trpceski; Justin Yerbury; Lezanne Ooi

 

 

Cell Stress and Chaperones

Small heat shock proteins: multifaceted proteins with important implications for life

Serena Carra; Simon Alberti; Justin Benesch; Wilbert Boelens; Johannes Buchner; John Carver; Ciro Cecconi; Heath Ecroyd; Nikolai Gusev; Lawrence Hightower

 

Cells

The Ubiquitin Proteasome System Is a Key Regulator of Pluripotent Stem Cell Survival and Motor Neuron Differentiation 

Monique Bax; Jessie McKenna; Dzung Do-Ha; Claire Stevens; Sarah Higginbottom; Rachelle Balez; Mauricio e Castro Cabral-Da-Silva; Natalie Farrawell; Martin Engel; Philip Poronnik

 

Cellular Immunology

Long-term treatment with the P2X7 receptor antagonist Brilliant Blue G reduces liver inflammation in a humanized mouse model of graft-versus-host disease

N Geraghty; D Watson; R Sluyter              

 

Chem Comm

Highly diastereoselective synthesis of enantioenriched anti-α-allyl-β-fluoroamines

Philip Chevis; Sirilak Wangngae; Thanaphat Thaima; Anthony Carroll; Anthony Willis; Mookda Pattarawarapan; Stephen Pyne

 

Chemical Communications

Divergent gold-catalysed reactions of cyclopropenylmethyl sulfonamides with tethered heteroaromatics

Melanie Drew; Sebastian Arndt; Christopher Richardson; Matthias Rudolph; A. Stephen Hashmi; Christopher Hyland

 

Chemical Science

The partial dehydrogenation of aluminium dihydrides

Thomas Hooper; Samantha Lau; Wenyi Chen; Ryan Brown; Marti Garcon; Karen Luong; Nathan Barrow; Andrew Tatton; George Sackman; Christopher Richardson

 

Chemical Science

Divergent Pd-catalyzed cross-coupling of allenyloxazolidinones to give chiral 1,3-dienes and vinyloxazolidinones

Ronald Brown; Farzad Zamani; Michael Gardiner; Haibo Yu; Stephen Pyne; Christopher Hyland

 

Chemistry and Physics of Lipids

Reaction of ionised steryl esters with ozone in the gas phase

Sarah Hancock; Alan Maccarone; Berwyck Poad; Adam Trevitt; Todd Mitchell; Stephen Blanksby

 

Chemistry: An Asian Journal

Heteroatom-doped MoSe2 Nanosheets with Enhanced Hydrogen Evolution Kinetics for Alkaline Water Splitting

Guoqiang Zhao; Xingyong Wang; Shaolan Wang; Kun Rui; Yaping Chen; Haibo Yu; Jing Ma; Shi Dou; Wenping Sun

 

Clinical Mass Spectrometry

Development and evaluation of matrix application techniques for high throughput mass spectrometry imaging of tissues in the clinic

Lennart Huizing; Shane Ellis; Bart Beulen; Florian Barré; Paul Kwant; Rob Vreeken; Ron Heeren

 

Communications in Computer and Information Science Data Mining: 16th Australasian Conference, AusDM 2018 Bathurst, NSW, Australia, November 28–30, 2018 Revised Selected Papers

An alternating least square based algorithm for predicting patient survivability

Qiming Hu; Jie Yang; Khin Win; Xufeng Huang

 

Critical Reviews in Toxicology

Nano-sunscreens – a double-edged sword in protecting consumers from harm: viewing Australian regulatory policies through the lenses of the European Union

S Solaiman; Jennifer Algie; Shahnaz Bakand; Ronald Sluyter; Vitor Sencadas; Michael Lerch; Xu-Feng Huang; Konstantin Konstantinov; Philip Barker

 

Crystal Growth and Design

Large Pore Isoreticular Strontium-Organic Frameworks: Syntheses, Crystal Structures, and Thermal and Luminescent Properties

Afsaneh Khansari; Shane Telfer; Christopher Richardson

 

CrystEngComm

High temperature expulsion of thermolabile groups for pore-space expansion in metal-organic frameworks

Macguire Bryant; Timothy Ablott; Shane Telfer; Lujia Liu; Christopher Richardson

 

CrystEngComm

Interpenetration isomers in isoreticular amine-tagged zinc MOFs

Afsaneh Khansari; Macguire Bryant; Daniel Jenkinson; Geoffrey Jameson; Omid Qazvini; Lujia Liu; Andrew Burrows; Shane Telfer; Christopher Richardson

 

 

Current Drug Targets

The urokinase plasminogen activation system in rheumatoid arthritis: Pathophysiological roles and prospective therapeutic targets

Benjamin Buckley; Umar Ali; Michael Kelso; Marie Ranson            

 

Current Drug Targets

Current understanding of Group A Streptococcal biofilms

Heema Vyas; Emma-Jayne Proctor; Jason McArthur; Jody Gorman; Martina Sanderson-Smith

 

Current Opinion in Biomedical Engineering

Spy-ing on Cas9: Single-molecule tools reveal the enzymology of Cas9

Kelsey Whinn; Antoine van Oijen; Harshad Ghodke

 

Current Organic Synthesis

The History of the Glycosidase Inhibiting Hyacinthacine C-type Alkaloids: From Discovery to Synthesis

Anthony Carroll; Stephen Pyne 

 

DNA Repair

Role of RNase H enzymes in maintaining genome stability in Escherichia coli expressing a steric-gate mutant of pol V<inf>ICE391</inf>

Erin Walsh; Sarah Henrikus; Alexandra Vaisman; Karolina Makiela-Dzbenska; Thomas Armstrong; Krystian Lazowski; John McDonald; Myron Goodman; Antonius van Oijen; Piotr Jonczyk

 

Ecotoxicology and Environmental Safety

Utilization of electrocoagulation for the isolation of alkaloids from the aerial parts of Stemona aphylla and their mosquitocidal activities against Aedes aegypti

Sirinrat Chalom; Kanlaya Jumpatong; Sunanta Wangkarn; Somporn Chantara; Chitchol Phalaraksh; Srisulak Dheeranupattana; Wannapa Suwankerd; Stephen Pyne; Pitchaya Mungkornasawakul

 

eLife

Spatial and temporal organization of RecA in the Escherichia coli DNA-damage response

Harshad Ghodke; Bishnu Paudel; Jacob Lewis; Slobodan Jergic; Kamya Gopal; Zachary Romero; Elizabeth Wood; Roger Woodgate; Michael Cox; Antoine van Oijen

 

European Journal of Medicinal Chemistry

Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles: synthesis, antibacterial evaluation and preliminary mechanism of action studies

Andrew Tague; Papanin Putsathit; Katherine Hammer; Steven Wales; Daniel Knight; Thomas Riley; Paul Keller; Stephen Pyne

 

European Journal of Medicinal Chemistry

Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles targeting Clostridioides (Clostridium) difficile: synthesis, antibacterial evaluation and an in vivo C. difficile infection model

Andrew Tague; Papanin Putsathit; Melanie Hutton; Katherine Hammer; Steven Wales; Daniel Knight; Thomas Riley; Dena Lyras; Paul Keller; Stephen Pyne

 

Faraday Discussions

Selecting and identifying gas-phase protonation isomers of nicotineH+ using combined laser, ion mobility and mass spectrometry techniques

Samuel Marlton; Benjamin McKinnon; Boris Ucur; Alan Maccarone; William Donald; Stephen Blanksby; Adam Trevitt

 

FASEB Journal

Self-derived structure-disrupting peptides targeting methionine aminopeptidase in pathogenic bacteria: A new strategy to generate antimicrobial peptides

Jian Zhan; Husen Jia; Evgeny Semchenko; Yunqiang Bian; Amy Zhou; Zhixiu Li; Yuedong Yang; Jihua Wang; Sohinee Sarkar; Makrina Totsika

 

Fitoterapia

A tocotrienol quinone dimer and xanthones from the leaf extract of Garcinia nigrolineata

Achara Raksat; Wisanu Maneerat; Raymond Andersen; Stephen Pyne; Surat Laphookhieo

 

Fitoterapia

Uvarialuridols A-C, three new polyoxygenated cyclohexenes from the twig and leaf extracts of Uvaria lurida

Virayu Suthiphasilp; Wisanu Maneerat; Raymond Andersen; Brian Patrick; Piyaporn Phukhatmuen; Stephen Pyne; Surat Laphookhieo

 

Frontiers In Cell And Developmental Biology

Generation of Vestibular Tissue-Like organoids From Human Pluripotent Stem Cells Using the Rotary Cell Culture System

Cristiana Mattei; Rebecca Lim; Hannah Drury; Babak Nasr; Zihui Li; Melissa Tadros; Giovanna D'Abaco; Kathryn Stok; Bryony Nayagam; Mirella Dottori   

        

Frontiers In Neuroscience

Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD

Thomas Hedl; Rebecca San Gil; Flora Cheng; Stephanie Rayner; Jennilee Davidson; Alana De Luca; Maria Villalva; Heath Ecroyd; Adam Walker; Albert Lee

 

Frontiers in Psychiatry

Patients with drug-naive bipolar disorder in remission after 8 weeks of treatment had decreased serum uric acid concentrations 

Jing-Xu Chen; Li-Gang Zhang; Ke-Zhi Liu; Hong-Mei Chen; Shuang-Jiang Zhou; Ning Wang; Yun-Long Tan; Shao-Li Wang; Alison Jones; Fu-De Yang

 

Human Molecular Genetics

Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice

Yajuvinder Singh; Henri Leinonen; Feroze Fazaludeen; Merja Jaronen; Debbie Guest; Noel Buckley; Nadiya Byts; Petra Oksa; Kari Jalkanen; Imran Iqbal

 

Immunology and Cell Biology

Pharmacological blockade of the CD39/CD73 pathway but not adenosine receptors augments disease in a humanized mouse model of graft-versus-host disease

Nicholas Geraghty; Debbie Watson; Ronald Sluyter

 

Infection and Immunity

Identification of a Conserved, Orphan G Protein-Coupled Receptor Required for Efficient Pathogen Clearance in Caenorhabditis elegans

Alexandra Anderson; Yee Chew; William Schafer; Rachel McMullan          

 

Inorganica Chimica Acta

Dynamic solution behaviour of metal complexes of the hexaamine cage ligand Me8tricosane

Leighton Alcock; German Cavigliasso; Douglas Lawes; Robert Stranger; James Hook; Stephen Ralph

 

International Immunopharmacology

The A2A receptor agonist CGS 21680 has beneficial and adverse effects on disease development in a humanised mouse model of graft-versus-host disease

N Geraghty; S Adhikary; D Watson; R Sluyter       

 

International Journal of Cancer 

Paracrine recruitment and activation of fibroblasts by c-Myc expressing breast epithelial cells through the IGFs/IGF-1R axis

Anna De Vincenzo; Stefania Belli; Paola Franco; Marialucia Telesca; Ingram Iaccarino; Gerardo Botti; Maria Carriero; Marie Ranson; Maria Stoppelli

 

International Journal of Mass Spectrometry

Experimental evidence for long-range stabilizing and destabilizing interactions between charge and radical sites in distonic ions

David Marshall; Ganna Gryn'ova; Berwyck Poad; Steven Bottle; Adam Trevitt; Michelle Coote; Stephen Blanksby

 

International Journal of Mass Spectrometry

Class-specific depletion of lipid ion signals in tissues upon formalin fixation

D Vos; Andrew Bowman; Ron Heeren; Benjamin Balluff; Shane Ellis           

 

Investigative Ophthalmology and Visual Science

Molecular Processes Implicated in Human Age-Related Nuclear Cataract

Roger Truscott; Michael Friedrich

 

Journal of Autism and Developmental Disorders

A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children

Hajar Mazahery; Cathryn Conlon; Kathryn Beck; Owen Mugridge; Marlena Kruger; Welma Stonehouse; Carlos Camargo Jr.; Barbara Meyer; Bobby Tsang; Beatrix Jones

 

Journal of Cleaner Production

Activated carbon preparation from biomass feedstock: Clean production and carbon dioxide adsorption 

Mohammad  Ahmed; Md Abu Hasan Johir; John Zhou; Huu Ngo; Long Nghiem; Christopher Richardson; Mohammad  Moni; Macguire Bryant 

 

Journal of Clinical Pathology

Is high-risk cutaneous squamous cell carcinoma of the head and neck a suitable candidate for current targeted therapies?

Catherine Zilberg; Matthew Lee; Spiridoula Kraitsek; Bruce Ashford; Marie Ranson; Kerwin Shannon; N Iyer; Sydney Ch'ng; Tsu-Hui (Hubert) Low; Carsten Palme        

 

Journal of Computational Chemistry

Quantum Chemical Methods for Modeling Covalent Modification of Biological Thiols

Ernest Awoonor-Williams; William Isley; Stephen Dale; Erin Johnson; Haibo Yu; Axel Becke; Benoit Roux; Christopher Rowley

 

Journal of Investigative Dermatology

Mutational Patterns in Metastatic Cutaneous Squamous Cell Carcinoma 

Simon Mueller; Marie-Emilie Gauthier; Bruce Ashford; Ruta Gupta; Velimir Gayevskiy; Sydney Ch'ng; Carsten Palme; Kerwin Shannon; Jonathan Clark; Marie Ranson

 

Journal of Lipid Research

Analytical separations for lipids in complex, nonpolar lipidomes using differential mobility spectrometry

Sarah Hancock; Berwyck Poad; Mark Willcox; Stephen Blanksby; Todd Mitchell

 

Journal of Molecular Biology

Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding     

Adam Quek; Blake Mazzitelli; Guojie Wu; Eleanor Leung; Tom Caradoc-Davies; Gordon Lloyd; Dharshini Jeevarajah; Paul Conroy; Martina Sanderson-Smith; Yue Yuan

 

Journal of Natural Products

Polyoxygenated Cyclohexenes and Their Chlorinated Derivatives from the Leaves of Uvaria cherrevensis

Chiramet Auranwiwat; Puttandon Wongsomboon; Thanaphat Thaima; Roonglawan Rattanajak; Sumalee Kamchonwongpaisan; Anthony Willis; Surat Laphookhieo; Stephen Pyne; Thunwadee Limtharakul

 

Journal of Natural Products

Corrected Structure of Natural Hyacinthacine C <inf>1</inf> via Total Synthesis

Anthony Carroll; Anthony Willis; Masako Hoshino; Atsushi Kato; Stephen Pyne

 

Journal of Natural Products

Amides and Flavonoids from the Fruit and Leaf Extracts of Melodorum siamensis

Wuttichai Jaidee; Raymond Andersen; Miguel Chavez; Yan Wang; Brian Patrick; Stephen Pyne; Chatchai Muanprasat; Suparerk Borwornpinyo; Surat Laphookhieo

 

Journal of Natural Products

α-Glucosidase Inhibitory Flavonoids and Oxepinones from the Leaf and Twig Extracts of Desmos cochinchinensis

Pornphimol Meesakul; Christopher Richardson; Stephen Pyne; Surat Laphookhieo

 

Journal of Natural Products

Antibacterial and Inhibitory Activities against Nitric Oxide Production of Coumaronochromones and Prenylated Isoflavones from Millettia extensa

Achara Raksat; Wisanu Maneerat; Narawadee Rujanapun; Raymond Andersen; Stephen Pyne; Surat Laphookhieo

 

Journal of Natural Products

Mallopenins A-E, Antibacterial Phenolic Derivatives from the Fruits of Mallotus philippensis

Sarot Cheenpracha; Stephen Pyne; Brian Patrick; Raymond Andersen; Wisanu Maneerat; Surat Laphookhieo        

 

Journal of Natural Products

Dasymaschalolactams A-E, Aristolactams from a Twig Extract of Dasymaschalon dasymaschalum

Virayu Suthiphasilp; Wisanu Maneerat; Raymond Andersen; Piyaporn Phukhatmuen; Stephen Pyne; Surat Laphookhieo

 

Journal of Natural Products

Phloroglucinol Benzophenones and Xanthones from the Leaves of Garcinia cowa and Their Nitric Oxide Production and α-Glucosidase Inhibitory Activities

Achara Raksat; Piyaporn Phukhatmuen; Jianxiong Yang; Wisanu Maneerat; Rawiwan Charoensup; Raymond Andersen; Yan Wang; Stephen Pyne; Surat Laphookhieo

 

Journal of Neurochemistry

Novel dual-action prodrug triggers apoptosis in glioblastoma cells by releasing a glutathione quencher and lysine-specific histone demethylase 1A inhibitor

Martin Engel; Yi Sing Gee; Dale Cross; Alan Maccarone; Benjamin Heng; Amy Hulme; Grady Smith; Gilles Guillemin; Brett Stringer; Christopher Hyland           

 

Journal of Neuropathology and Experimental Neurology

Increased Tau Phosphorylation in Motor Neurons From Clinically Pure Sporadic Amyotrophic Lateral Sclerosis Patients

Claire Stevens; Natalie Guthrie; Marloes van Roijen; Glenda Halliday; Lezanne Ooi

 

Journal of Nutritional Biochemistry

Alterations to the microbiota–colon–brain axis in high-fat-diet-induced obese mice compared to diet-resistant mice

Peng Zhang; Yinghua Yu; Yanfang Qin; Yuan Zhou; Renxian Tang; Qingling Wang; Xiangyang Li; Hongqin Wang; Katrina Weston-Green; Xu-Feng Huang

 

Journal of Organic Chemistry

Desymmetrization Reactions of Indigo with Grignard Reagents for the Synthesis of Selective Antiplasmodial [1 H,3′ H]-3-Aryl-2,2′-diindol-3′-ones

Nicholas Butler; John Bremner; Anthony Willis; Leonardo Lucantoni; Vicky Avery; Paul Keller

 

Journal of Physical Chemistry B 

Mechanisms of Pressure-Induced Structural Transformation in Confined Sodium Borate Glasses 

Thi Thuy Huong Ta; Anh Tieu; Hongtao Zhu; Haibo Yu; Nam Van Tran; Thi Ta

 

Journal of Proteomics

Strategies for managing multi-patient 3D mass spectrometry imaging data

D Vos; I Jansen; M Lucas; Martin Paine; O de Boer; S Meijer; C Savci-Heijink; H Marquering; D de Bruin; Ron Heeren

 

Journal of Psychopharmacology

Perinatal exposure to fluoxetine increases anxiety- and depressive-like behaviours and alters glutamatergic markers in the prefrontal cortex and hippocampus of male adolescent rats: A comparison between Sprague-Dawley rats and the Wistar-Kyoto rat model of depression

Samuel Millard; Jeremy Lum; Francesca Fernandez; Katrina Weston-Green; Kelly Newell

 

Journal of the American Society for Mass Spectrometry

Conditions for Analysis of Native Protein Structures Using Uniform Field Drift Tube Ion Mobility Mass Spectrometry and Characterization of Stable Calibrants for TWIM-MS 

Julian Harrison; Celine Kelso; Tara Pukala; Jennifer Beck

 

Journal of the American Society for Mass Spectrometry

Mapping Unsaturation in Human Plasma Lipids by Data-Independent Ozone-Induced Dissociation

David Marshall; Angela Criscuolo; Reuben Young; Berwyck Poad; Martin Zeller; Gavin Reid; Todd Mitchell; Stephen Blanksby

 

Journal of the American Society for Mass Spectrometry

Combining Charge-Switch Derivatization with Ozone-Induced Dissociation for Fatty Acid Analysis

Berwyck Poad; David Marshall; Eva Harazim; Rajesh Gupta; Venkateswara Narreddula; Reuben Young; Eva Duchoslav; J Campbell; James Broadbent; Josef Cvacka

 

Malaysian Journal of Nutrition

Sensitivity of plasma cholecystokinin and peptide YY in obese and normal weight men

Dian Handayani; Inggita Kusumastuty; Sri Andarini; Nindy Sabrina; Achmad Rudijanto; Xu-Feng Huang

 

Medicinal Research Reviews

Effects of antipsychotic drugs on neurites relevant to schizophrenia treatment

Xu-Feng Huang; Xueqin Song

 

Methods in Molecular Biology

Generation of Neural Crest Progenitors from Human Pluripotent Stem Cells

Kwaku Dad Abu-Bonsrah; Serena Viventi; Donald Newgreen; Mirella Dottori

 

Methods in Molecular Biology

Monoclonal antibody-conjugated dendritic nanostructures for siRNA delivery

Hitesh Kulhari; Ashok Jangid; David Adams

 

Microbes and Infection: a journal on infectious agents and host defenses

Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection

Diane Ly; Deborah Donahue; Mark Walker; Victoria Ploplis; Jason McArthur; Marie Ranson; Francis Castellino; Martina Sanderson-Smith

 

Microfluidics and Nanofluidics

Dean-flow-coupled elasto-inertial particle and cell focusing in symmetric serpentine microchannels

Dan Yuan; Ronald Sluyter; Qianbin Zhao; Shiyang Tang; Sheng Yan; Guolin Yun; Ming Li; Jun Zhang; Weihua Li

 

Molecular Phylogenetics and Evolution

Drivers of sociality in Gobiodon fishes: An assessment of phylogeny, ecology and life-history

Martin Hing; O Klanten; Marian Wong; Mark Dowton

 

Molecules

Shining a spotlight on DNA: Single-molecule methods to visualise DNA

Gurleen Kaur; Jacob Lewis; Antoine van Oijen

 

Molecules

Synthesis and density functional theory studies of azirinyl and oxiranyl functionalized isoindigo and (3Z,3′Z)-3,3′-(ethane-1,2-diylidene)bis(indolin-2-one) derivatives

Gholamhossein Khalili; Patrick McCosker; Timothy Clark; Paul Keller

 

Molecules

Anti-infective and anti-cancer properties of the Annona species: Their ethnomedicinal uses, alkaloid diversity, and pharmacological activities

Ari Nugraha; Yuvita Damayanti; Phurpa Wangchuk; Paul Keller

 

Nano Energy

Electrocatalytically inactive SnS2 promotes water adsorption/dissociation on molybdenum dichalcogenides for accelerated alkaline hydrogen evolution

Yaping Chen; Xingyong Wang; Mengmeng Lao; Kun Rui; Xiaobo Zheng; Haibo Yu; Jing Ma; Shi Dou; Wenping Sun

 

Natural Product Communications: an international journal for communications and reviews

Production and Antifungal Activity of Cordytropolone and (-)-Leptosphaerone A From the Fungus Polycephalomyces nipponicus

Nilawan Surapong; Aphidech Sangdee; Kittipong Chainok; Stephen Pyne; Prapairat Seephonkai

 

Natural Product Communications: an international journal for communications and reviews

Phytochemical and pharmacological studies on four Indonesian epiphytic medicinal plants: Drynaria rigidula, Hydnophytum formicarum, Usnea misaminensis, and Calymperes schmidtii

Ari Nugraha; Tashi Wangchuk; Anthony Willis; Rachada Haritakun; Heri Sujadmiko; Paul Keller

 

Natural Product Research

Chemical diversity and anti-acne inducing bacterial potentials of essential oils from selected Elsholtzia species

Sopit Phetsang; Jukreera Panyakaew; Sunanta Wangkarn; Nopakarn Chandet; Angkhana Inta; Sila Kittiwachana; Stephen Pyne; Pitchaya Mungkornasawakul       

 

Natural Product Research

Antimalarial and cytotoxic activities of pregnene-type steroidal alkaloids from Holarrhena pubescens roots

Sarot Cheenpracha; Pannakorn Boapun; Thunwadee Limtharakul; Surat Laphookhieo; Stephen Pyne

 

Natural Product Research

Phytochemical studies on the Australian native plant species Acacia pycnantha and Jacaranda mimosifolia D.Don

Rudi Hendra; Paul Keller

 

Natural Product Research

Alkaloids from the root of Indonesian Annona muricata L

Ari Nugraha; Rachada Haritakun; Jacob Lambert; Carolyn Dillon; Paul Keller

 

Natural Product Research

A new xanthone and a biphenyl from the flower and twig extracts of Garcinia mckeaniana

Chiramet Auranwiwat; Thunwadee Limtharakul; Stephen Pyne; Roonglawan Rattanajak; Sumalee Kamchonwongpaisan

 

Natural Product Research

(R)-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of Anomianthus dulcis and their antimalarial and cytotoxic activities

Thanika Promchai; Thanaphat Thaima; Roonglawan Rattanajak; Sumalee Kamchonwongpaisan; Stephen Pyne; Thunwadee Limtharakul

 

Nature Genetics

Comparative genetic architectures of schizophrenia in East Asian and European populations

Max Lam; Chia-Yen Chen; Zhiqiang Li; Alicia Martin; Julien Bryois; Xixian Ma; Helena Gaspar; Masashi Ikeda; Beben Benyamin; Brielin Brown

 

Neural Regeneration Research

Strategies to promote the maturation of ALS-associated SOD1 mutants: Small molecules return to the fold

Luke McAlary; Justin Yerbury     

 

Neurochemical Research

Understanding the Role of ApoE Fragments in Alzheimer’s Disease

Sonia Sanz Munoz; Brett Garner; Lezanne Ooi

 

Neuroscience Letters

The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS

Justin Yerbury; Lezanne Ooi; Ian Blair; Prajwal Ciryam; Christopher Dobson; Michele Vendruscolo

 

Neuroscientist 

Modeling Emergent Properties in the Brain Using Tissue Models to Investigate Neurodegenerative Disease

Alexander Harris; Patrick McGivern; Lezanne Ooi

 

Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms

Stigmatic imaging of secondary ions in MeV-SIMS spectrometry by linear Time-of-Flight mass spectrometer and the TimePix detector

Bostjan Jencic; Luka Sepec; Primoz Vavpetic; Mitja Kelemen; Zdravko Rupnik; Matjaz Vencelj; Katarina Vogel-Mikus; Nina Ogrinc Potocnik; Shane Ellis; Ron Heeren

 

Nucleic Acids Research

RecFOR epistasis group: RecF and RecO have distinct localizations and functions in Escherichia coli

Sarah Henrikus; Camille Henry; Harshad Ghodke; Elizabeth Wood; Neema Mbele; Roopashi Saxena; Upasana Basu; Antonius van Oijen; Michael Cox; Andrew Robinson

 

Nucleic Acids Research

Recycling of single-stranded DNA-binding protein by the bacterial replisome

Lisanne Spenkelink; Jacob Lewis; Slobodan Jergic; Zhi-Qiang Xu; Andrew Robinson; Nicholas Dixon; Antoine van Oijen               

 

Nutritional Neuroscience

A Mediterranean-style dietary intervention supplemented with fish oil improves diet quality and mental health in people with depression: A randomized controlled trial (HELFIMED)

Natalie Parletta; Dorota Zarnowiecki; Jihyun Cho; Amy Wilson; Svetlana Bogomolova; Anthony Villani; Catherine Itsiopoulos; Theo Niyonsenga; Sarah Blunden; Barbara Meyer

 

Organic and Biomolecular Chemistry

1,2-Addition versus homoconjugate addition reactions of indoles and electron-rich arenes to α-cyclopropyl N -acyliminium ions: Synthetic and computational studies

Greg Ryder; Uta Wille; Anthony Willis; Stephen Pyne

 

Organic Letters

Benzoazepine-Fused Isoindolines via Intramolecular (3 + 2)-Cycloadditions of Azomethine Ylides with Dinitroarenes

Steven Wales; Daniel Rivinoja; Michael Gardiner; Melissa Bird; Adam Meyer; John Ryan; Christopher Hyland

 

Organometallics

Phosphine-Scavenging Cationic Gold(I) Complexes: Alternative Applications of Gold Cocatalysis in Fundamental Palladium-Catalyzed Cross-Couplings

Curtis Ho; Alireza Ariafard; Christopher Hyland; Alex Bissember 

 

Oxidative Medicine And Cellular Longevity

Alpha-2-Macroglobulin, a Hypochlorite-Regulated Chaperone and Immune System Modulator

Jordan Cater; Mark Wilson; Amy Wyatt 

 

Pathology

Expression of cancer stem cell markers is prognostic in metastatic gastroesophageal adenocarcinoma

Daniel Brungs; Alistair Lochhead; Anita Iyer; Martin Illemann; Peter Colligan; Nicholas Hirst; Ashleigh Splitt; Winston Liauw; Kara Vine; Sarennya Pathmanandavel      

 

Pharmacognosy Research

Antidiarrheal activity of some selected Nigerian plants used in traditional medicine

Christiana Dawurung; Jurbe Gotep; Joy Usman; Ishaku Elisha; Lami Lombin; Stephen Pyne

 

Physical Chemistry Chemical Physics

Product detection study of the gas-phase oxidation of methylphenyl radicals using synchrotron photoionisation mass spectrometry

Matthew Prendergast; Benjamin Kirk; John Savee; David Osborn; Craig Taatjes; Patrick Hemberger; Stephen Blanksby; Gabriel da Silva; Adam Trevitt    

 

Phytochemistry

Alkaloids and styryllactones from Goniothalamus cheliensis

Wuttichai Jaidee; Raymond Andersen; Brian Patrick; Stephen Pyne; Chatchai Muanprasat; Suparerk Borwornpinyo; Surat Laphookhieo

 

Plant Cell and Environment

BSD2 is a Rubisco-specific assembly chaperone, forms intermediary hetero-oligomeric complexes, and is nonlimiting to growth in tobacco

Brendon Conlan; Rosemary Birch; Celine Kelso; Sophie Holland; Amanda De Souza; Stephen Long; Jennifer Beck; Spencer Whitney

 

Proceedings of the National Academy of Sciences of the United States of America

A gatekeeping function of the replicative polymerase controls pathway choice in the resolution of lesion-stalled replisomes

Seungwoo Chang; Karel Naiman; Elizabeth Thrall; James Kath; Slobodan Jergic; Nicholas Dixon; Robert Fuchs; Joseph Loparo

 

Proceedings Of The National Academy Of Sciences Of The United States Of America

Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia- and Alzheimer’s-associated amyloid beta peptide

Jordan Cater; Janet Kumita; Rafaa Abdallah; Guomao Zhao; Ana Bernardo-Gancedo; Amanda Henry; Wendy Winata; Mengna Chi; Brin Grenyer; Michelle Townsend 

 

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Aripiprazole and haloperidol protect neurite lesions via reducing excessive D2R-DISC1 complex formation

Peng Zheng; Minmin Hu; Yuanyi Xie; Yinghua Yu; Hanna Jaaro-Peled; Xu-Feng Huang       

 

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Effect of cannabidiol on endocannabinoid, glutamatergic and GABAergic signalling markers in male offspring of a maternal immune activation (poly I:C) model relevant to schizophrenia

Ashleigh Osborne; Nadia Solowij; Ilijana Babic; Jeremy Lum; Kelly Newell; Xu-Feng Huang; Katrina Weston-Green

 

Progress in Neuropsychopharmacology and Biological Psychiatry

Effect of cannabidiol on muscarinic neurotransmission in the pre-frontal cortex and hippocampus of the poly I:C rat model of schizophrenia

Carlos Jimenez Naranjo; Ashleigh Osborne; Katrina Weston-Green

 

Protein Science

A structural view of bacterial DNA replication

Aaron Oakley    

 

Psychiatric Genetics

Association of CamK2A genetic variants with transition time from occasional to regular heroin use in a sample of heroin-dependent individuals

Antonia Eirich; Teresa Biermann; Christian Muller; Johannes Kornhuber; Beben Benyamin; Gary Hulse; Dieter Wildenauer; Sibylle Schwab        

 

Psychiatry Research

Early antipsychotic exposure affects NMDA and GABAA receptor binding in the brains of juvenile rats

Jiamei Lian; Chao Deng 

 

Psychiatry Research

Weight gain in Major Depressive Disorder: Linking appetite and disordered eating to leptin and ghrelin

Jessica Mills; Theresa Larkin; Chao Deng; Susan Thomas 

 

Psychoneuroendocrinology

Olanzapine-induced endoplasmic reticulum stress and inflammation in the hypothalamus were inhibited by an ER stress inhibitor 4-phenylbutyrate

Meng He; Xu-Feng Huang; Guanbin Gao; Ting Zhou; Wenting Li; Jinqi Hu; Jia Chen; Jing Li; Taolei Sun

 

Psychopharmacology

Modulation by chronic antipsychotic administration of PKA- and GSK3β-mediated pathways and the NMDA receptor in rat ventral midbrain

Bo Pan; Chao Deng

 

Purinergic Signalling

Altered donor P2X7 activity in human leukocytes correlates with P2RX7 genotype but does not affect the development of graft-versus-host disease in humanised mice

S Adhikary; N Geraghty; P Cuthbertson; R Sluyter; D Watson

 

RSC Advances: an international journal to further the chemical sciences 

DC and AC magnetic fields increase neurite outgrowth of SH-SY5Y neuroblastoma cells with and without retinoic acid

Enad Abed Mahmood Alabed; Martin Engel; Yusuke Yamauchi; Md Shahriar Hossain; Lezanne Ooi

 

Schizophrenia Research

Comparison of erythrocyte omega-3 index, fatty acids and molecular phospholipid species in people at ultra-high risk of developing psychosis and healthy people

Ayedh Alqarni; Todd Mitchell; Patrick McGorry; Barnaby Nelson; Connie Markulev; Hok Yuen; Miriam Schafer; Maximus Berger; Nilufar Mossaheb; Monika Schloegelhofer

 

Schizophrenia Research

Supplementation with the omega-3 long chain polyunsaturated fatty acids: Changes in the concentrations of omega-3 index, fatty acids and molecular phospholipids of people at ultra high risk of developing psychosis            

Ayedh Alqarni; Todd Mitchell; Patrick McGorry; Barnaby Nelson; Connie Markulev; Hok Yuen; Miriam Schafer; Maximus Berger; Nilufar Mossaheb; Monika Schlogelhofer

 

Schizophrenia Research

Increased translocator protein (TSPO) binding throughout neurodevelopment in the perinatal phencyclidine rodent model of schizophrenia

Jeremy Lum; Teresa du Bois; Filomena Mattner; Andrew Katsifis; Samara Brown; Xu-Feng Huang; Kelly Newell     

 

Science Advances

Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-b aggregates

Tom Scheidt; Urszula Lapinska; Janet Kumita; Daniel Whiten; David Klenerman; Mark Wilson; Samuel Cohen; Sara Linse; Michele Vendruscolo; Christopher Dobson

 

Scientific Reports

Comparative studies of catalytic pathways for Streptococcus pneumoniae sialidases NanA, NanB and NanC

Kela Xiao; Xingyong Wang; Haibo Yu       

 

Scientific Reports

Nuclease dead Cas9 is a programmable roadblock for DNA replication

Kelsey Whinn; Gurleen Kaur; Jacob Lewis; Grant Schauer; Stefan Mueller; Slobodan Jergic; Hamish Maynard; Zhong Gan; Matharishwan Naganbabu; Marcel Bruchez

 

Scientific Reports

Maintenance of Deep Lung Architecture and Automated Airway Segmentation for 3D Mass Spectrometry Imaging

Alison Scott; Courtney Chandler; Shane Ellis; Ron Heeren; Robert Ernst

 

Scientific Reports

Increased throughput and ultra-high mass resolution in DESI FT-ICR MS imaging through new-generation external data acquisition system and advanced data processing approaches

Pieter Kooijman; Konstantin Nagornov; Anton Kozhinov; David Kilgour; Yury Tsybin; Ron Heeren; Shane Ellis          

 

Scientific Reports

Three-Dimensional Mass Spectrometry Imaging Identifies Lipid Markers of Medulloblastoma Metastasis

Martin Paine; Jingbo Liu; Danning Huang; Shane Ellis; Dennis Trede; Jan Kobarg; Ron Heeren; Facundo Fernández; Tobey MacDonald

 

Small Methods

Theoretical Screening of Single Transition Metal Atoms Embedded in MXene Defects as Superior Electrocatalyst of Nitrogen Reduction Reaction

Lei Li; Xingyong Wang; Haoran Guo; Ge Yao; Haibo Yu; Ziqi Tian; Baihai Li; Liang Chen

 

Stem Cell Reports

PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

Henna Konttinen; Mauricio e Castro Cabral-Da-Silva; Sohvi Ohtonen; Sara Wojciechowski; Anastasia Shakirzyanova; Simone Caligola; Rosalba Giugno; Yevheniia Ishchenko; Damian Hernandez; Mohammad Fazaludeen       

 

Stem Cell Research

Generation and characterization of a human induced pluripotent stem cell line UOWi005-A from dermal fibroblasts derived from a CCNF<sup>S621G</sup> familial amyotrophic lateral sclerosis patient using mRNA reprogramming

Monique Bax; Rachelle Balez; Sonia Sanz Munoz; Dzung Do-Ha; Claire Stevens; Tracey Berg; Mauricio Cabral-da-Silva; Martin Engel; Garth Nicholson; Shu Yang

 

Stem Cells International

Organotypic Cocultures of Human Pluripotent Stem Cell Derived-Neurons with Mammalian Inner Ear Hair Cells and Cochlear Nucleus Slices

Tomoko Hyakumura; Stuart McDougall; Sue Finch; Karina Needham; Mirella Dottori; Bryony Nayagam

 

Tetrahedron

Structure elucidation of cyclohexene (9Z)-octadec-9-enyl ethers isolated from the leaves of Uvaria cherrevensis (Annonaceae)

Chiramet Auranwiwat; Alan Maccarone; Anthony Carroll; Roonglawan Rattanajak; Sumalee Kamchonwongpaisan; Stephen Blanksby; Stephen Pyne; Thunwadee Limtharakul

 

Tetrahedron

Progress toward the total synthesis of 9β-hydroxyvertine: Construction of an advanced quinolizidine intermediate

Thanaphat Thaima; Anthony Willis; Stephen Pyne

 

The FASEB Journal

Human glycan expression patterns influence Group A streptococcal colonization of epithelial cells

David De Oliveira; Arun Everest-Dass; Lauren Hartley-Tassell; Christopher Day; Anuk Indraratna; Stephan Brouwer; Ailish Cleary; Liisa Kautto; Jody Gorman; Nicolle Packe

 

The FASEB Journal

Regulation of mitochondrial metabolism in murine skeletal muscle by the medium-chain fatty acid receptor Gpr84

Magdalene Montgomery; Brenna Osborne; Amanda Brandon; Liam O'Reilly; Corrine Fiveash; Simon Brown; Brendan Wilkins; Azrah Samsudeen; Josephine Yu; Beena Devanapalli

 

The International Journal of Biochemistry and Cell Biology

Bombesin receptors as potential targets for anticancer drug delivery and imaging

Deep Pooja; Anusha Gunukula; Nitin Gupta; David Adams; Hitesh Kulhari

 

The Journal Of Experimental Biology

Honey bee caste lipidomics in relation to life-history stage and the long life of the queen

Nicolas Martin; A Hulbert; Greg Brenner; Simon Brown; Todd Mitchell; Paul Else

 

The Journal of Physical Chemistry A: Isolated Molecules, Clusters, Radicals, and Ions; Environmental Chemistry, Geochemistry, and Astrochemistry; Theory

Molecular weight growth in the gas phase reactions of dehydroanilinium radical cations with propene

Patrick Kelly; Cameron Bright; Stephen Blanksby; Gabriel da Silva; Adam Trevitt

 

The Journal of Steroid Biochemistry and Molecular Biology

A randomised controlled trial of vitamin D and omega-3 long chain polyunsaturated fatty acids in the treatment of irritability and hyperactivity among children with autism spectrum disorder

Hajar Mazahery; Cathryn Conlon; Kathryn Beck; Owen Mugridge; Marlena Kruger; Welma Stonehouse; Carlos Camargo Jr.; Barbara Meyer; Beatrix Jones; Pamela von Hurst

 

Transplant Immunology Increased splenic human CD4+:CD8+ T cell ratios, serum human interferon-γ and intestinal human interleukin-17 are associated with clinical graft-versus-host disease in humanized mice

Nicholas Geraghty; Lisa Belfiore; Sam Adhikary; Stephen Alexander; Ronald Sluyter; Debbie Watson

 

Trends in Analytical Chemistry

Advances in mass spectrometry imaging enabling observation of localised lipid biochemistry within tissues

Andrew Bowman; Ron Heeren; Shane Ellis

 

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