- Animal House
- Animal Models
- Cryostorage
- Electrophysiology and calcium imaging
- Exosome Analysis
- Flow cytometry
- Gene expression analysis
- Histopathology
- Mammalian cell culture
- Mass spectrometry
- Microscopy
- Organic synthesis and analysis
- Production of recombinant proteins in bacteria and insect cells
- Production of recombinant proteins in mammalian cells
- Protein aggregation, chaperone assays
- Radiation imaging
- RNA analysis
- Single molecule fluorescence analyses
- Small molecule x-ray diffraction
- Stem cell and differentiation
- Transmission and cryoelectron microscopy
Small animal housing, procedure rooms, IVIS animal imaging system
Rodent models of cancer, bacterial infection, neuropsychiatric illness & treatment, cognition, & graft versus host disease.
High capacity cryostorage of mammalian and other cell types
The electrophysiology facility includes (patchliner, syncropatch, microelectrode arrays (MEAs)).
Equipment available (funding source):
- Syncropatch‐384 (ARC LIEF, UOW)
- Patchliner (ARC LIEF, UQ)
- Port a patch (SEG, UQ)
- HiClamp (MEG, RMIT)
- MEA2100 systems (REG, UOW)
- Fluorescence calcium imaging
Contact:
- Distinguished Professor David Adams (syncropatch and patch liner)
- Professor Lezanne Ooi (calcium imaging and MEAs.)
Exosome purification and characterisation
Multiparametric cellular and particle analyses, live cell sorting
Nanostring gene expression profiling
Histology, immunochemistry, biomarker measurement
In vitro tumour and bacterial infection models, transfection, drug discovery
Mass spectrometry (MS) analyses of small to large molecules; MS imaging, lipidomics; laser photodissociation MS
High throughput live cell imaging, high resolution confocal imaging, calcium imaging, single molecule imaging (TIRF), FRET and FLIM
Synthetic and medicinal chemistry, catalysis, NMR, chiral HPLC
Expression and purification of recombinant proteins from bacteria and insect cells
Expression and purification of post-translationally modified proteins from mammalian cells
In vitro and C. elegans models of protein aggregation and related diseases, studies of protein folding, phase separation, and degradation
Radiation imaging in animals and humans
Single cell and spatial transcriptomics, single molecule in situ hybridisation
Single molecule fluorescence microscopy, molecular biophysics, fluorescent biosensors, microfluidics
Small molecule X-ray diffraction, organic and inorganic materials chemistry
Contact: Professor Mirella Dottori
CryoEM imaging of macromolecules, negative staining EM, shadow-casting EM