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Dr Michael J KelsoPosition: Lecturer Room: 18.115 Phone No: +61 2 4221 5085 E-mail: mkelso@uow.edu.au |
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Research Interests
Medicinal chemistry, drug design and synthesis, structure-based drug design, prodrug design and synthesis, anti-tumour agents, anti-microbial agents, DNA binding anthracyclines, biofilm dispersing agents, catalytic asymmetric synthesis
Representative Publications:
Peptides and Small Molecules Targeting the Plasminogen Activation System: Towards Prophylactic Anti-Metastasis Drugs for Breast Cancer. Tyndall, J. D. A.; Kelso, M. J.; Clingan, P.; Ranson, M. Recent Patents on Anti-Cancer Drug Discovery. 2008, 3, 1-13.
Synthesis of an Anthracyclinone Bearing an Unprecedented Aromatic Ring-Fused Bridgehead-Hydroxylated Bicyclo[3.1.1] heptanol. Kelso, C.; Beck, J.L.; Kelso, M.J. Tetrahedron Lett. 2007, 48, 7440-7443.
Structure-Activity Relationships of Alpha-Ketooxazole Inhibitors of Fatty Acid Amide Hydrolase. Hardouin C.; Kelso, M.J.; Romero, F.A.; Rail, T.J; Leung, D.; Hwang, I.; Cravatt, B.F.; Boger, D.L. J. Med. Chem. 2007, 50(14), 3359-3368.
Catalytic Enantioselective Conjugate Addition of Carbamates. Palomo, C.; Oiarbide, M.; Halder, R.; Kelso, M.; Gomez-Bengoa, E.; Garcia, J-M. J. Am. Chem. Soc. 2004, 126 (30): 9188-9189.
Alpha-Turn Mimetics: Short Peptide Alpha-Helices Composed of Cyclic Metallopentapeptide Modules. Kelso, M. J.; Beyer, R. L.; Hoang, H. N.; Lakdawala, A. S.; Snyder, J. P.; Oliver, W. V.; Robertson, T. A.; Appleton, T. G.; Fairlie, D. P. J. Am. Chem. Soc. 2004, 126 (15), 4828-4842.
Current Approaches to Peptidomimetics. Kelso, M. J.; Fairlie, D. P. in Molecular Pathomechanisms and New Trends in Drug Research. Keri, G.; Toth, I. (Eds.). 2003. Taylor & Francis Ltd., London, PP. 579-598. (Review).
Conformationally Homogeneous Cyclic Tetrapeptides: Useful New Three Dimensional Scaffolds. Glenn, M. P.; Kelso, M. J.; Tyndall, J. D. A.; Fairlie, D. P. J. Am. Chem. Soc. 2003, 125 (3), 640-641.
Conformationally Constrained Macrocycles that Mimic Tripeptide Beta-Strands in Water and Aprotic Solvents. Reid, R. C.; Kelso, M. J.; Scanlon, M. J.; Fairlie, D. P. J. Am. Chem. Soc. 2002, 124 (20), 5673-5683.
Current Students
DRUGS FOR THE PREVENTION OF TUMOUR METASTASIS
PhD:
Hayden Matthews Inhibitors of Plasminogen Activation for the Prevention of Breast Cancer Metastasis
Suggested Topics for Future Students
• Synthesis and DNA Binding Properties of Novel Anthracyclines
• Improving the Effectiveness of Paclitaxel Chemotherapy
• Cytotoxin-Angiogenesis Inhibitor Prodrug Hybrids Selectively Activated by Tumour Hypoxia
• Inhibitors of Plasminogen Activation for the Prevention of Breast Cancer Metastasis
• Dual-Action Anti-Infectives for Combating Bacterial Drug Resistance
• Development of Antibiotics Against Drug Resistant Clostridium difficile
• Biofilm Dispersing Agents: A New Strategy for Eradicating Drug Resistant Pseudomonas aeruginosa Biofilm Infections
Abbreviated CV
Academic Qualifications
B.Med. Chem. (Hons 1), University of Wollongong, 1996 (University Medal for the Faculty of Science)
Ph.D., Institute for Molecular Bioscience, University of Queensland, 2002 (with Professor David Fairlie)
Positions held
Lecturer, School of Chemistry, University of Wollongong, Australia. January 2008 - Current.
NHMRC CJ Martin Research Fellow, School of Chemistry, University of Wollongong, Australia. January 2006 - January 2008.
NHMRC CJ Martin Research Fellow, Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA (with Professor Dale Boger) January 2004 - December 2005.
Postdoctoral Research Fellow, Universidad del Pais Vasco, San Sebastian, Spain (with Professor Claudio Palomo and Professor Mikel Oiarbide) December 2002 - December 2003.
Postdoctoral Research Fellow, Institute for Molecular Bioscience, University of Queensland (with Professor David Fairlie) March 2002 - November 2002.