Nick Dixon
Position: Professor
Room: 18.G10
Phone No: +61 2 4221 4346
E-mail: nickd@uow.edu.au
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Research Interests
• Biological chemistry
• Protein structure and function
• Protein-protein interactions in large dynamic molecular machines
• The bacterial DNA replication machinery as a target for antibacterial drugs
• New technologies for protein chemistry
Representative Publications
M. D. Mulcair, P. M. Schaeffer, A. J. Oakley, H. F. Cross, C. Neylon, T. M. Hill and N. E. Dixon, "A molecular mousetrap determines polarity of termination of DNA replication in E. coli" Cell, 125, 1309–1319 (2006).
G. Pintacuda, A. Y. Park, M. A. Keniry, N. E. Dixon and G. Otting, G., "Lanthanide labeling offers fast NMR approach to 3D structure determinations of protein–protein complexes" J. Am. Chem. Soc., 128, 3696–3702 (2006).
C. M. Elvin, A. G. Carr, M. G. Huson, J. M. Maxwell, R. D. Pearson, T. Vuocolo, N. E. Liyou, D. C. C. Wong, D. J. Merritt and N. E. Dixon, "Synthesis and properties of crosslinked recombinant pro-resilin" Nature, 437, 999–1002 (2005).
C. Neylon, A. V. Kralicek, T. M. Hill and N. E. Dixon, "Replication termination in Escherichia coli: Structure and anti-helicase activity of the Tus-Ter complex" Microbiol. Mol. Biol. Rev., 69, 501–526 (2005).
N. K. Williams, E. Liepinsh, S. J. Watt, P. Prosselkov, J. M. Matthews, P. Attard, J. L. Beck, N. E. Dixon, and G. Otting, "Stabilization of native protein fold by intein-mediated covalent cyclization" J. Mol. Biol., 346, 1095–1108 (2005).
L. Guignard, K. Ozawa, S. E. Pursglove, G. Otting and N. E. Dixon, "NMR analysis of in vitro-synthesized proteins without purification: a high-throughput approach" FEBS Lett., 524, 159–162 (2002).
S. Hamdan, P. D. Carr, S. E. Brown, D. L. Ollis and N. E. Dixon, "Structural basis for proofreading during replication of the Escherichia coli chromosome" Structure, 10, 535–546 (2002).
B. P. Dalrymple, K. Kongsuwan, G. Wijffels, N. E. Dixon and P. A. Jennings, "A universal protein-protein interaction motif in the eubacterial DNA replication and repair systems" Proc. Natl. Acad. Sci. USA, 98, 11627–11632 (2001).
M. Bárcena, T. Ruiz, L. E. Donate, S. E. Brown, N. E. Dixon, M. Radermacher and J. M. Carazo, "The DnaB•DnaC complex: a structure based on asymmetric interactions among dimers assembled around an occluded channel" EMBO J., 20, 1462–1468 (2001).
Current Students
Research Fellows
Dr Hara Ioannou: Protein Functions in DNA Replication
Dr Andrew Robinson: Nucleic Acid Synthesis in Bacterial Pathogens
Dr Slobodan Jergic: Protein-protein Interactions in the Bacterial Replisome
Dr Thitima Urathamakul: How DNA-binding Proteins Recognize DNA
Dr Dom Bellini: Structure and Function of DNA Helicases
Suggested Topics for Future Students
Positions Available
1. PhD Scholarship in structural biology and protein engineering (APAI)
Please link to: http://www.uow.edu.au/research/rsc/student/scholarships/index.html
2. Two research associate positions will be advertised early in 2008. Enquiries from suitable qualified postdoctoral researchers are welcome.
Abbreviated CV
Professor Nick Dixon holds a PhD in Biochemistry from the University of Queensland (1978). He was a Research Fellow with Prof Alan Sargeson (Research School of Chemistry, ANU) before being awarded C.J. Martin and Fulbright Fellowships to study with Nobel laureate Prof Arthur Kornberg at Stanford University, U.S.A. He returned to the John Curtin School of Medical Research at ANU as a Queen Elizabeth II Fellow in 1983, and was appointed as Fellow in Biological Chemistry at the Research School of Chemistry, ANU in 1986. He was subsequently promoted to Senior Fellow and Professor, before leaving ANU in 2006 to take up his present position as Professor of Biological Chemistry at the University of Wollongong. He was recently awarded an Australian Research Council Australian Professorial Fellowship.
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