Stephen Pyne
Position: Professor
Room: 18.121
Phone No: +61 2 42213511
E-mail: spyne@uow.edu.au
Lab: 18.207
Lab Phone: +61 2 4221 4388
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Research Interests
New methods for the asymmetric synthesis of bioactive molecules. The total synthesis of bioactive natural products, especially alkaloids. Natural products and fullerene chemistry.
Research Details (pdf 122k)
Representative Publications
Asymmetric Synthesis of (-)-Swainsonine, (+)-1,2-di-epi-Swainsonine and (+)-1,2,8-tri-epi-Swainsonine, K. B. Lindsay, and S. G. Pyne, J. Org. Chem., 2002 67, 7774-7780.
Phytochemical and Larvicidal Studies on Stemona curtisii Hook. F: Structure of a new Pyrido[1,2-a]azepine Stemona Alkaloid, S. G. Pyne, A. Jatisatienr, D. Supyen, W. Lie, A. T. Ung, B. W. Skelton, and A. H. White, J. Nat. Prod. 2004, 67, 675-677.
Synthesis of Putative Uniflorine A, A. S. Davis, S. G. Pyne, B. W. Skelton and A. H. White, J. Org. Chem. 2004, 69, 3139-3143.
Asymmetric Synthesis of Anti-1,2-Amino Alcohols via the Borono-Mannich Reaction: A Formal Synthesis of (-)-Swainsonine, C. W. G. Au and S. G. Pyne, J. Org. Chem. 2006, 71, 7097-7099.
Synthesis of novel 3'-spirocyclic-oxindole derivatives and assessment of their cytostatic activities, S. R. Yong, A. T. Ung, S. G. Pyne, B. W. Skelton and A. H. White, Tetrahedron, 2007, 63, 5579-5586.
Searchable Publication List
Publications List (pdf 172k)
Current Students
ASYMMETRIC SYNTHESIS OF BIOACTIVE ALKALOIDS
Recent Review of our Research (PDF 1.6M)
PhD:
Andrew Davis Asymmetric Synthesis of Indolizidine Alkaloids
Arife Yazici Asymmetric Synthesis of Stemona Alkaloids
Marc Boullion Asymmetric Synthesis of Polyhydroxylated Pyrrolidines
Christopher Au Asymmetric Synthesis of Polyhydroxylated Pyrrolizidine alkaloids
Thunwadee Rittiwigrom Asymmetric Synthesis of Indolizidine Alkaloids
Kumar Swamy Asymmetric Synthesis of Stemona Alkaloids
Panawan Moosophon (visiting) Asymmetric Synthesis of Calystegine Alkaloids
DRUG DESIGN AND SYNTHESIS
MSc:
Parastoo Jafari Development of histamine agonists
NATURAL PRODUCTS CHEMISTRY
Dr. Pitchaya Mungkornasawakul (Endeavour Fellow and ARC Post Doc) Stemona alkaloid chemistry and biology
PhD:
Kwankamol Sastraruji Stemona alkaloid chemistry and biology
FULLERENE CHEMISTRY
Rajeswari Thayumanavan Regioselective Synthesis of Fullerenyl amino acids and peptides
Suggested Topics for Future Students
Asymmetric Synthesis of Bioactive Alkaloids
Drug Design and Synthesis
Natural Products Chemistry
Fullerene Chemistry
Abbreviated CV
Academic qualifications
B.Sc.(Hons), University of Adelaide, 1975, Top first class honours, (Organic Chemistry)
Ph.D., Australian National University, 1979 (with Prof. L. N. Mander)
Positions held
Postdoctoral Research Fellow, Purdue University, USA, April 1979-June 1981.
Postdoctoral Research Fellow, Harvard University, USA, July 1981-July 1983.
Research Fellow, LaTrobe University, Victoria, October 1983 to January 1985.
Lecturer (1985-88), Senior Lecturer (1989-92), A. Prof (1993-7), Professor (1998-) Department of Chemistry, University of Wollongong,
CV (pdf 215k)
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