John Bremner
Position Honorary Professorial Fellow
Room 18.123
Phone No +61 2 4221 4255
E-mail john_bremner@uow.edu.au
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Research Interests
My research interests are based on the three interacting themes of medicinal chemistry, synthetic heterocyclic chemistry and natural products chemistry. The long term goal is centred on the development of new selective medicinal agents for the treatment of infectious disease and cancer.
Representative Publications
Ball, A.R., Casadei, G., Samosorn, S., Bremner, J.B., Ausubel, F.M., Moy, T.I., and Lewis, K., ‘Conjugating Berberine to a Multidrug Resistance Pump Inhibitor Creates an Effective Antimicrobial’, ACS Chemical Biology, 2006, 1, 594-600.
Bremner, J.B., Ambrus, J.I., and Samosorn, S., ‘Dual Action-Based Approaches to Antibacterial Agents’, Curr. Med. Chem., 2007, 14, 1459-1477.
Vine,K.L, Locke, J.M., Ranson, M. Pyne, S.G., and Bremner, J.B., ‘An Investigation into the Cytotoxicity and Mode of Action of Some Novel N-alkyl Substituted Isatins, J. Med. Chem., 2007, 50, 5109-5117.
Gornall, K.C., Samosorn, S., Talib, J., Bremner, J.B., and Beck, J.L., ‘Selectivity of an Indolyl Berberine Derivative for Tetrameric G-Quadruplex DNA’, Rapid Commun. Mass Spectrom., 2007, 21, 1759-1766.
Current Students
PhD:
Joseph Ambrus Dual Action Drugs and Prodrugs as Anti-infectives
Neal Dalton Peptide based integrase inhibitors
(Co-supervisor: Assoc Prof Paul Keller)
Lidia Matesic Isatin-based Anti-cancer Agents
(Principal Supervisor: Dr Danielle Skropeta; Co- and Associate Supervisors: Assoc. Prof. Marie Ranson; Dr Julie Locke; Dr Kara Vine)
Karina Gornall Selective DNA Binding Ligands as a Basis for New Therapeutics (Principal Supervisor: Dr. Jenny Beck)
Abbreviated CV
Qualifications
1964 BSc (1st Class Hons.) (University of Western Australia);
1968 PhD (Australian National University);
1975 Dip. Chem. Pharmacol. (University of Edinburgh); 1980 FRACI; 1991 FRSC.
Professional Experience
1967-1968 Harvard University Research Fellow in Chemistry;
1968-1991 University of Tasmania
Lecturer in Chemistry (1968-73);
Senior Lecturer (1974-80); Reader (1981-91);
Head, Department of Chemistry (1990-91).
1991-2007 University of Wollongong Professor of Organic Chemistry.
2007- University of Wollongong Honorary Professorial fellow, Chemistry
1994-2000 University of Wollongong Head, Department of Chemistry.
2001-2004 University of Wollongong Director, Institute for Biomolecular Science.
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