Jenny Beck   Position:   Associate Professor in Biological Chemistry Room:   18.104 Phone No:   +61 2 4221 4177 Email:   jbeck@uow.edu.au Lab:   18.103 Lab Phone:   +61 2 4221 5943

Research Interests

Investigating the assembly of the E. coli replisome and other biological molecular machines using a variety of techniques with electrospray ionization mass spectrometry as the major tool.

Studying drug-DNA interactions

Ion mobility mass spectrometry of proteins, drugs and DNA

Developing clinical tests for plasma and urinary proteins that are disease markers.

Click here for more details on research projects.

 

Representative Publications

Gornall, K. C., Samosorn, S., Talib, J., Bremner, J. B., and Beck, J. L. (2007) Selectivity of an indolyl berberine derivative for tetrameric G-quadruplex DNA. Rapid Communications in Mass Spectrometry 21, 1759-1766.

Watt, S. J., Urathamakul, T., Schaeffer, P. M., Williams, N. K., Sheil, M. M., Dixon, N. E., and Beck, J. L. (2007) Multiple oligomeric forms of Escherichia coli DnaB helicase revealed by electrospray ionisation mass spectrometry. Rapid Communications in Mass Spectrometry 21, 132-140.

Beck, J. L., Urathamakul, T., Watt, S. J., Sheil, M. M., Schaeffer, P. M., and Dixon, N. E. (2006) Proteomic dissection of DNA polymerization. Expert Review of Proteomics 3, 197-211.

Williams, N. K., Liepinsh, E., Watt, S. J., Prosselkov, P., Matthews, J. M., Attard, P., Beck, J. L., Dixon, N. E., and Otting, G. (2005) Stabilization of Native Protein Fold by Intein-Mediated Covalent Cyclization. Journal of Molecular Biology 346, 1095-1108.

Gupta, R., Hamdan, S. M., Dixon, N. E., Sheil, M. M., and Beck, J. L. (2004) Application of electrospray ionization mass spectrometry to study the hydrophobic interaction between the  and  subunits of DNA polymerase III. Protein Science 13, 2878-2887.

Searchable Publication List

 

Current Students

PhD:

Celine Kelso 
Interactions of novel anthracyclines with DNA

Linda Jessop
The Clamp Loader Complex of the E.coli replisome

Karina Gornall (with Dr Michael Kelso and advisor Prof.  John Bremner)
Interactions of novel compounds with quadruplex DNA

Michelle Blayney
ATPases and DNA bunding proteins of molecular machines 

Tak Yiu Lo (with Prof. Nick Dixon)
Analysis of Plasma Proteins by ESI-MSAnalysis of Multiprotein Complexes by ESI-MS

Claire Mason (with Prof. Nick Dixon)
Interactions of single-stranded DNA binding protein with DNA

 

Suggested Topics for Future Students

Interactions of rubisco with rubisco activase.

Interactions among proteins of the E.coli replisome.

 

Abbreviated CV

BSc (Hons I), PhD from UQ

Postdoctoral fellowships held at U. Illinois (Urbana-Champaign) and ANU

Current position: Associate Professor in Biological Chemistry (Chemistry Dept, UoW)