Stephen Pyne

Position:		Professor
Room:		18.121
Phone No:		+61 2 4221 3511
Email:		spyne@uow.edu.au
Lab:		18.207
Lab Phone:		+61 2 4221 4388

Research Interests

New methods for the asymmetric synthesis of bioactive molecules. The total synthesis of bioactive natural products, especially alkaloids, the synthesis of novel amino acids (selective glutamate agonists and antagonists), anti-cancer agents, antibiotics, anti-HIV and immunosuppressive agents. Natural products and fullerene chemistry.

Research Details (pdf 122k)

Representative Publications

Asymmetric Synthesis of (-)-Swainsonine, (+)-1,2-di-epi-Swainsonine and (+)-1,2,8-tri-epi-Swainsonine, K. B. Lindsay, and S. G. Pyne, J. Org. Chem., 2002 67, 7774-7780.

The Synthesis and Characterisation of Mono- and Bis-methano[60]fulleryl Amino Acid Derivatives and their Reductive Ring-Opening Retro-Bingel Reactions, G. A. Burley, P. A. Keller, S. G. Pyne and G. E. Ball, J. Org. Chem. 2002, 67, 8316-8330.

Chemo-Enzymatic Synthesis of (-)-Epipentenomycin I, T. Klomklao S. G. Pyne, A. Baramee, B. W. Skelton and A. H. White, Tetrahedron: Asymmetry, 2003, 14, 3885-3889.

Phytochemical and Larvicidal Studies on Stemona curtisii Hook. F: Structure of a new Pyrido[1,2-a]azepine Stemona Alkaloid, S. G. Pyne, A. Jatisatienr, D. Supyen, W. Lie, A. T. Ung, B. W. Skelton, and A. H. White, J. Nat. Prod. 2004, 67, 675-677.

Synthesis of Putative Uniflorine A, A. S. Davis, S. G. Pyne, B. W. Skelton and A. H. White, J. Org. Chem. 2004, 69, 3139-3143.

Searchable Publication List
Publications List (pdf 346k)

Current Students

ASYMMETRIC SYNTHESIS OF BIOACTIVE ALKALOIDS

Recent Review of our Research (PDF 1.6M)

Andrew Davis: (PhD)

Asymmetric Synthesis of Indolizidine Alkaloids

Theeraphan Machan: (PhD)

Asymmetric Synthesis of Indolizidine Alkaloids and Natural Product Chemistry

Nicole Gates: (PhD)

Asymmetric Synthesis of Polyhydroxylated Pyrrolidines

Christopher Au: (MSc)

DRUG DESIGN AND SYNTHESIS

Stephen Taylor: (PhD)

Design and Synthesis of Novel Biaryl Anticancer Agents

Uta Batenbug-Nguyen: (PhD)

Design and Synthesis of Novel Bisisoquinoline Anticancer Agents

Sarah Yong: (PhD)

Design and Synthesis of CDK2 inhibitors Agents

NATURAL PRODUCTS CHEMISTRY

Theeraphan Machan (PhD)

FULLERENE CHEMISTRY

Bill Hawkins: (PhD)

Regioselective Synthesis of Polyfunctionalized Fullerenes

James Williams: (Hons)

Regioselective Synthesis of Polyfunctionalized Fullerenes

Abbreviated CV

Academic qualifications

B.Sc.(Hons), University of Adelaide, 1975, Top first class honours, (Organic Chemistry)
Ph.D., Australian National University, 1979 (with Prof. L. N. Mander)

Positions held

Postdoctoral Research Fellow, Purdue University, USA, April 1979-June 1981.
Postdoctoral Research Fellow, Harvard University, USA, July 1981-July 1983.
Research Fellow, LaTrobe University, Victoria, October 1983 to January 1985.
Lecturer (1985-88), Senior Lecturer (1989-92), A. Prof (1993-7), Professor (1998-) Department of Chemistry, University of Wollongong, February 1985-1988.

CV (pdf 493k)