Paul Keller   Position:   Associate Professor Room:   18. 222 Phone No:   +61 2 4221 4692 Email:   paul_keller@uow.edu.au Lab/other loc:   18.220 Lab Phone:   +61 2 4221 3510

Research Interests

Bioorganic and Medicinal Chemistry

The design and synthesis of new agents for therapeutic use. Techniques include:

organic synthesis, including methodology development, with an emphasis on the asymmetric synthesis of sterically hindered systems, spiro compounds, and new fullerenyl derivatives.

 

Computer-aided molecular modeling, with the design of new targets and methodology development investigating flexible protein systems.

 

Chiral Ligand Design for the Stereoselective Synthesis of Sterically Hindered Systems

Drug Design and Development

New Anti-HIV

 

The Fight for Life - Targeting the Prevention of Premature Birth

New Synthetic Fullerene Chemistry.

The Development of Computer-Aided Molecular Modeling Techniques

 

Representative Publications

Bremner , J. B.; Coates, J. A.; Coghlan, D. R.; David, D. M.; Keller, P. A.; Pyne, S. G.; The Synthesis of A Novel Binaphthyl-Based Cyclic Peptoid with Anti-Bacterial Activity, N. J. Chem . 2002 , 26 ,1549-1552.

Burley, G. A.; Keller, P. A.; Pyne, S. G.; Ball, G. E.; The Synthesis and Characterisation of Mono- and Bis-methano[60]fulleryl Amino Acid Derivatives and their Reductive Ring-Opening Retro-Bingel Reactions J. Org. Chem. , 2002 , 67 , 8316-8330.

Griffith, R.; Luu, T. T. T.; Garner, J.; Keller , P. A. Combining Structure-Based Drug Design and Pharmacophores. J. Mol. Graph. 2005 , 23 , 439-446.

Bringmann, G.; Price Mortimer, A. J.; Keller, P. A. ; Garner, J.; Gresser, M. J.; Breuning, M. Modern Concepts for the Atropselective Synthesis of Axially Chiral Biaryls. Angew. Chem. 2005 , 44

Searchable Publication List

 

Current Students

Research Fellows:

Mark Robertson
Novel Peptide Antibiotics

James Garner
The Design and Synthesis of New Reverse Transcriptase Inhibitors for Anti-AIDS Therapy

Leila Chaker
Multifunctionalised Fullerene Chemistry

PhD:

Catherine Hemley
CRH Antagonists as Therapeutics for the Prevention of Premature Birth

Mary Gresser
Design & Synthesis of Chiral Nitrogen and Arsine -based Ligands for the Stereoselective Synthesis of Sterically Hindered Systems

Chris Gordon
Study of HIV-I integrase synthesis of inhibitors conformational analysis and integration of drug design

Bill Hawkins
Design and Synthesis of Multifunctionalised Fullerenyl Amino Acids

Pam Sumner
Radiolabelled Growth Factor RTK Inhibitors as Antitumour Agents

Andrew Stirling
Conformationally Restricted CRH Antagonists

Neal Dalton
New Anti-HIV Therapeutics

Allan Gamble
Design and Synthesis of Potential HIV Reverse Transcriptase Inhibitors

James Williams
Fullerenyl Amino Acid Synthesis

Taryn Homes
Design and Synthesis of Radiolabelled Compounds for the Diagnosis and Therapy of Melanomoa

Stephen Wales
Design & Synthesis of Chiral Phosphine -based Ligands for the Stereoselective Synthesis of Sterically Hindered Systems

 

Suggested Topics for Future Students

Abbreviated CV

Qualification

PhD University of New South Wales (1991)
BSc(Hons) University of New South Wales (1985)

Positions Held

Senior Lecturer, Bio-Organic and Medicinal Chemistry, University of Wollongong
Co-ordinator, Bachelor of Medicinal Chemistry Degree
Member, Institute ofr Biomolecular Science (Drug Design and Bio-Organic Synthetic Chemistry)

ARGS Research Assistant (1986), UNSW.

Alexander von Humboldt Post-Doctoral Fellow (1992-94 and 2001),

CURRENT FUNDING

ARC Linkage x2, ARC Australian Centre for Nanostructured Electromaterials, AINSE, Industry