Bioorganic and Medicinal Chemistry
The design and synthesis of new agents for therapeutic use. Techniques include:
organic synthesis, including methodology development, with an emphasis on the asymmetric synthesis of sterically hindered systems, spiro compounds, and new fullerenyl derivatives.
Computer-aided molecular modeling, with the design of new targets and methodology development investigating flexible protein systems.
Chiral Ligand Design for the Stereoselective Synthesis of Sterically Hindered Systems
Drug Design and Development
New Anti-HIV
The Fight for Life - Targeting the Prevention of Premature Birth
New Synthetic Fullerene Chemistry.
The Development of Computer-Aided Molecular Modeling Techniques
Bremner , J. B.; Coates, J. A.; Coghlan, D. R.; David, D. M.; Keller, P. A.; Pyne, S. G.; The Synthesis of A Novel Binaphthyl-Based Cyclic Peptoid with Anti-Bacterial Activity, N. J. Chem . 2002 , 26 ,1549-1552.
Burley, G. A.; Keller, P. A.; Pyne, S. G.; Ball, G. E.; The Synthesis and Characterisation of Mono- and Bis-methano[60]fulleryl Amino Acid Derivatives and their Reductive Ring-Opening Retro-Bingel Reactions J. Org. Chem. , 2002 , 67 , 8316-8330.
Griffith, R.; Luu, T. T. T.; Garner, J.; Keller , P. A. Combining Structure-Based Drug Design and Pharmacophores. J. Mol. Graph.
2005 , 23 , 439-446.
Bringmann, G.; Price Mortimer, A. J.; Keller, P. A. ; Garner, J.; Gresser, M. J.; Breuning, M. Modern Concepts for the Atropselective Synthesis of Axially Chiral Biaryls. Angew. Chem.
2005 , 44
Searchable Publication List
Research Fellows:
Mark Robertson
Novel Peptide Antibiotics
James Garner
The Design and Synthesis of New Reverse Transcriptase Inhibitors for Anti-AIDS Therapy
Leila Chaker
Multifunctionalised Fullerene Chemistry
PhD:
Catherine Hemley
CRH Antagonists as Therapeutics for the Prevention of Premature Birth
Mary Gresser
Design & Synthesis of Chiral Nitrogen and Arsine -based Ligands for the Stereoselective Synthesis of Sterically Hindered Systems
Chris Gordon
Study of HIV-I integrase synthesis of inhibitors conformational analysis and integration of drug design
Bill Hawkins
Design and Synthesis of Multifunctionalised Fullerenyl Amino Acids
Pam Sumner
Radiolabelled Growth Factor RTK Inhibitors as Antitumour Agents
Andrew Stirling
Conformationally Restricted CRH Antagonists
Neal Dalton
New Anti-HIV Therapeutics
Allan Gamble
Design and Synthesis of Potential HIV Reverse Transcriptase Inhibitors
James Williams
Fullerenyl Amino Acid Synthesis
Taryn Homes
Design and Synthesis of Radiolabelled Compounds for the Diagnosis and Therapy of Melanomoa
Stephen Wales
Design & Synthesis of Chiral Phosphine -based Ligands for the Stereoselective Synthesis of Sterically Hindered Systems
Senior Lecturer, Bio-Organic and Medicinal Chemistry, University of Wollongong
Co-ordinator, Bachelor of Medicinal Chemistry Degree
Member, Institute ofr Biomolecular Science (Drug Design and Bio-Organic Synthetic Chemistry)
ARGS Research Assistant (1986), UNSW.
Alexander von Humboldt Post-Doctoral Fellow (1992-94 and 2001),