Mark Wilson Position:   Professor and Associate Dean Research, Science Room:   35.120A Phone No:   +61 2 4221 4534 Email:   mrw@uow.edu.au Lab Phone:   +(61) 2 4221 4306

Research Interests

Extracellular chaperones

Quality control of extracellular protein folding

Cellular analyses (e.g. flow cytometry, confocal microscopy)

Additional Research Information

 

Representative Publications

Wilson, M R and Easterbook-Smith, S B (2000) Clusterin is a secreted mammalian chaperone. Trends Biochem. Sci. 25: 95-98

Yerbury, J., Rybchyn, M., Easterbrook-Smith, S., Henriques, C. and Wilson, M R. (2005) The acute phase protein haptoglobin is a mammalian extracellular chaperone with an action similar to clusterin. Biochemistry 44: 10914-10925

Yerbury, J., Stewart, E., Wyatt, A. and Wilson, M R. (2005) Quality control of protein folding in extracellular space. EMBO Reports 6: 1131-1136

Yerbury, JJ, Poon, S, Meehan, S, Thompson, B, Kumita, JR, Dobson, CM and Wilson, M R. (2007) The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with pre-fibrillar structures. FASEB J. 21: 2312-2322

French, K, Yerbury, JJ and Wilson, M R. (2008) Protease activation of alpha-2-macroglobulin modulates a chaperone-like action with broad specificity. Biochemistry 47: 1176-1185

Searchable Publication List

 

Post-doctoral Fellows

Dr Stephen Poon

Establishing the role of clusterin in extracellular quality control of protein folding

Dr Justin Yerbury

 Extracellular chaperones and disease

 

Current Students

PhD

Amy Wyatt

Disposal of misfolded extracellular proteins

Rebecca Dabbs

Development of clusterin as a novel immunological adjuvant

 

Honours

Natalie Farrawell

           Defining the chaperone binding site(s) of alpha-2-macroglobulin

 

Suggested Topics for Future Students

(i) Development of recombinant sources of extracellular chaperones for potential therapeutic applications.

(ii) Investigating the involvement of extracellular chaperones in inflammatory disease.

See Also the Honours Topics Page

 

Abbreviated CV

Employment History

Associate Dean (Research) Science 2007 -

Professor, University of Wollongong, 2004 -

Associate Professor, University of Wollongong, 2000- 2004

Senior Lecturer, University of Wollongong 1996- 1999

Lecturer, University of Wollongong 1994-1995

The Medical Foundation Medical Research Fellow 1993

NH&MRC Research Officer / Snr Research Officer, Dept. of Biochemistry, Univ. of Sydney, 1990-1992

Research Fellow, Department of Biochemistry, Univ.of Sydney, 1988-90

Research Scientist, Monoclonal Australia Ltd., 65 Dickson Ave., Artarmon, 2064, 1986-88

NH&MRC Research Officer, Clinical Immunology, Univ. of Sydney, 1986

NH&MRC Research Assistant, Clinical Immunology, Univ. of Sydney, 1985

Academic Degrees

PhD The University of Sydney 1985

BSc (Hons) (First class) The University of Sydney 1980

Prizes, Scholarships, Fellowships and Awards

Outstanding Achievement in Teaching Award, Australian College of Education 1997

VC's Excellence in Teaching Award, University of Wollongong 1997

Travelling Fellowship The Faculty of Medicine, University of Sydney 1993

Medical Research Fellowship, The Medical Foundation 1993

Commonwealth Postgraduate Scholarship 1981-85

G.S.Caird Scholarship, Biology IIIE, The University of Sydney 1979

Haswell Prize, Biology IIIE, The University of Sydney 1978

G.S.Caird Scholarship, Biology IIE, The University of Sydney 1977