Mark Wilson
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| Position: |
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Professor and Associate Dean Research, Science |
| Room: |
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35.120A |
| Phone No: |
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+61 2 4221 4534 |
| Email: |
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mrw@uow.edu.au |
| Lab Phone: |
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+(61) 2 4221 4306 |
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Research Interests
Extracellular chaperones
Quality control of extracellular protein folding
Cellular analyses (e.g. flow cytometry, confocal microscopy)
Additional Research Information
Representative Publications
Wilson, M R and Easterbook-Smith, S B (2000) Clusterin is a secreted mammalian chaperone. Trends Biochem. Sci. 25: 95-98
Yerbury, J., Rybchyn, M., Easterbrook-Smith, S., Henriques, C. and Wilson, M R. (2005) The acute phase protein haptoglobin is a mammalian extracellular chaperone with an action similar to clusterin. Biochemistry 44: 10914-10925
Yerbury, J., Stewart, E., Wyatt, A. and Wilson, M R. (2005) Quality control of protein folding in extracellular space. EMBO Reports 6: 1131-1136
Yerbury, JJ, Poon, S, Meehan, S, Thompson, B, Kumita, JR, Dobson, CM and Wilson, M R. (2007) The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with pre-fibrillar structures. FASEB J. 21: 2312-2322
French, K, Yerbury, JJ and Wilson, M R. (2008) Protease activation of alpha-2-macroglobulin modulates a chaperone-like action with broad specificity. Biochemistry 47: 1176-1185
Searchable Publication List
Post-doctoral Fellows
Dr Stephen Poon
Establishing the role of clusterin in extracellular quality control of protein folding
Dr Justin Yerbury
Extracellular chaperones and disease
Current Students
PhD
Amy Wyatt
Disposal of misfolded extracellular proteins
Rebecca Dabbs
Development of clusterin as a novel immunological adjuvant
Honours
Natalie Farrawell
Defining the chaperone binding site(s) of alpha-2-macroglobulin
Suggested Topics for Future Students
(i) Development of recombinant sources of extracellular chaperones for potential therapeutic applications.
(ii) Investigating the involvement of extracellular chaperones in inflammatory disease.
Abbreviated CV
Employment History
Associate Dean (Research) Science 2007 -
Professor, University of Wollongong, 2004 -
Associate Professor, University of Wollongong, 2000- 2004
Senior Lecturer, University of Wollongong 1996- 1999
Lecturer, University of Wollongong 1994-1995
The Medical Foundation Medical Research Fellow 1993
NH&MRC Research Officer / Snr Research Officer, Dept. of Biochemistry, Univ. of Sydney, 1990-1992
Research Fellow, Department of Biochemistry, Univ.of Sydney, 1988-90
Research Scientist, Monoclonal Australia Ltd., 65 Dickson Ave., Artarmon, 2064, 1986-88
NH&MRC Research Officer, Clinical Immunology, Univ. of Sydney, 1986
NH&MRC Research Assistant, Clinical Immunology, Univ. of Sydney, 1985
Academic Degrees
PhD The University of Sydney 1985
BSc (Hons) (First class) The University of Sydney 1980
Prizes, Scholarships, Fellowships and Awards
Outstanding Achievement in Teaching Award, Australian College of Education 1997
VC's Excellence in Teaching Award, University of Wollongong 1997
Travelling Fellowship The Faculty of Medicine, University of Sydney 1993
Medical Research Fellowship, The Medical Foundation 1993
Commonwealth Postgraduate Scholarship 1981-85
G.S.Caird Scholarship, Biology IIIE, The University of Sydney 1979
Haswell Prize, Biology IIIE, The University of Sydney 1978
G.S.Caird Scholarship, Biology IIE, The University of Sydney 1977
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