A biorational approach to antibacterial lead compound
discovery in southern Australian marine molluscs
Project Summary:
The evolution of resistance to antibiotics presents a serious
problem and requires the development of new antimicrobial agents. Focussing
on southern Australian marine molluscs, this project will use a biorational
approach to drug discovery, which involves utilising the deductive powers of
biology. Specifically, it is hypothesised that antibacterial agents are widely
used to protect the egg stage of marine molluscs and that the biosynthesis of
antibacterial agents could be induced in adult molluscs in response to immunological
challenge. By examining molluscan taxa that have not been the focus of previous
natural products research it is predicted that some novel bioactive metabolites
could be identified.
Chief Investigator(s):
Wen Xu
2001 $
2002 $
2003 $
2004 $
2005 $
Total $
$72,276
$74,406
$76,534
$78,665
$80,792
$382,673
Fellowship Type
ARF
Project Title:
Generation of coherent-hypersound from semiconductor
systems
Project Summary:
Coherent-hypersound is an entirely new source of high frequency
ultrasound with a pure frequency and coherent nature. It can be extensively
applied in industry, medical treatment and scientific research, especially in
ultrasonic and electronic devices. In this project, I will investigate the generation
and propagation of coherent-hypersound with frequency~1 teraherts using state-of-the-art
semiconductor and laser techniques. I intend studying theoretically the coherent-hypersonic
generation via emission of coherent-phonons in GaAs- and GaN-based systems,
in conjunction with different experimental techniques. This project will be
carried out in collaboration with local and international experimental groups.
