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Dr Teresa du Bois

BSc (Hons), PhD

Position: 

• NHMRC/SRI Research Fellow

Teaching:

• BMS352 Fundamentals of Neuroscience
• BMS346 Motor Control and Dysfunction
• Honours and postgraduate research student supervision

Research Interests:

My research aims to determine how disrupting normal brain development can lead to mental disorders such as schizophrenia in later life. Using a developmental animal model of schizophrenia- perinatal PCP treatment, I examine how disruptions to the NMDA receptor, which plays a key role in brain development, affects other brain systems such as dopaminergic, GABAergic systems, and behaviour, in later life. I am also interested in the role that neuregulin1-ErbB4 signalling plays in schizophrenia pathology and how this system interacts with the NMDA receptor/glutamatergic system.

Publications:

Searchable RIS publications from 2000 to date.

Publications list (in reverse chronological order), including papers in press.

Referred journal articles (note IF= impact factor based on 2008 ISI Journal Citation Report):

du Bois TM, Newell KA, Han M, Deng C and Huang XF (2009). Excitatory and inhibitory neurotransmission is chronically altered following perinatal NMDA receptor blockade. European Neuropsychopharmacology 19: 256-265. (IF=3.661)

du Bois TM, Newell KA, Han M, Deng C and Huang XF (2009). Perinatal PCP treatment alters the developmental expression of prefrontal and hippocampal muscarinic receptors. Progress in Neuro-Psychopharmacology and Biological Psychiatry 33: 37-40. (IF=2.638)

du Bois TM, Hsu CW, Li Y, Tan YY, Deng C and Huang XF (2008). Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade. Neurochemical Research 33: 1224-1231. (IF=2.260)

du Bois TM, Huang XF and Deng C (2008). Perinatal administration of PCP alters adult behaviour in female Sprague-Dawley rats. Behavioural Brain Research 188: 416-419. (IF=3.171)

du Bois TM and Huang XF (2007). Early brain development disruption from NMDA receptor hypofunction: relevance to schizophrenia.  Brain Research Reviews 53: 260-270. (IF=6.236)

du Bois TM, Deng C, Bell W and Huang XF (2006). Fatty acids differentially affect serotonin receptor and transporter binding in the rat brain. Neuroscience 139: 1397-1403. (IF=3.556)

du Bois TM, Deng C, Bell W and Huang XF (2005). A high n-6 polyunsaturated fatty acid diet reduces muscarinic M2/M4 receptor binding in the rat brain. Journal of Chemical Neuroanatomy 29: 282-288. (IF=2.580)

du Bois TM, Deng C and Huang XF (2005). Membrane Phospholipid Composition, Alterations in Neurotransmitter Systems and Schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry 29: 879-889. (IF=2.638)

du Bois TM (2005). Schizophrenia, fats and lab rats. Rhizome 1: 17-24. (IF=N/A)

Book Chapters:

du Bois TM and Huang XF. Neurodevelopment, neurotransmitter imbalance and cognitive dysfunction in schizophrenia. In ‘New Frontiers in Neurological Research’ Research Signpost (In press). ISBN: 978-81-308-0284-8.